UNIVERSITY OF HAWAII SNRP

本提案是为响应RFA NS-99-001而编制的，并描述了该少数民族机构的专业神经科学研究计划。Bekesy神经生物学实验室为该SNRP提供了一个合适的网站，并将通过所要求的奖励得到极大的加强。三个初级教师已被选中，谁制定了合作的建议，涉及一个研究密集型机构的调查员。项目1-涉及从刺胞动物毒液中提取新的神经活性化合物。这项工作将与约翰霍普金斯大学的研究人员合作进行，他们在这一领域的工作是众所周知的。项目2-询问位于中枢神经系统内的细胞毒性T淋巴细胞是否导致对HIV-1的神经毒力株的选择，从而作为该选择过程的延迟结果启动AIDS痴呆综合征。这项工作将与西雅图的华盛顿大学的一名经验丰富的调查员合作进行。项目3-寻求表征的微生物剂负责一种形式的脑脊髓炎发现在特定的西伯利亚人口。然而，移民的流行率与本地人口相同。这项工作将与一名在传染病研究方面有经验的NINDS校内调查员合作进行。内部和外部咨询委员会已经成立，以进一步协助选定的教师在发展自己的独立神经科学研究事业。该奖项将大大提高机会不足的少数民族获得高质量的研究培训在神经科学在这个机构。

This proposal has been prepared in response to RFA NS-99-001, and describes a Specialized Neuroscience Research Program for this Minority Institution. The Bekesy Laboratory of Neurobiology provides an appropriate site for this SNRP and would be greatly strengthened by the requested award. Three junior faculty have been selected, who have developed collaborative proposals involving an investigator at a research- intensive institution. Project 1- involves characterization of novel neuroactive compounds from Cnidaria venoms. This work will be carried out in collaboration with investigators from Johns Hopkins University who are well-known for their work in this area. Project 2- asks whether cytotoxic T lymphocytes located within the central nervous system lead to selection on neurovirulent strains of HIV-1 thus initiating AIDS dementia complex as a delayed result of this selection process. This work will be carried out in collaboration with an experienced investigator at the University of Washington, Seattle. Project 3- seeks to characterize the microbial agent responsible for a form of encephalomyelitis found in a specific Siberian population. However, prevalence is the same in-migrants as in the native population. This work will be carried out in collaboration with an NINDS Intramural investigator experienced in study of infectious diseases. Internal and External Advisory committees have been established to further assist the selected faculty in developing their independent neuroscience research careers. This award will substantially improve opportunities for underserved minorities to obtain high-quality research training in neurosciences at this institution.