BRAIN ANATOMIC MRI IN CHILDHOOD BIPOLAR DISORDER

描述(改编自申请者摘要)：被指导对象的目标 临床科学家发展奖(K08)是为了允许候选人 通过实施以下计划发展成为独立的临床研究人员 脑部解剖磁学的培训和指导临床研究 儿童双相情感障碍的磁共振成像(MRI)尽管这口井 记录了儿童BPD的发病率和功能障碍，这种障碍仍然存在 儿童精神病理学中最具争议的话题之一，也是 结果，这是研究最少的儿童精神障碍之一。这 争议在很大程度上是神学上的。毫无疑问，这些都是 孩子是存在的。然而，这是缺乏足够的科学数据 童年的BPD，产生了怀疑和缺席的恶性循环 研究的成果。导致BPD诊断复杂化的一个主要因素是 儿童是ADHD的常见共病。关键问题是 这些儿童是否患有ADHD、BPD或两者兼有。的决议案 这个问题具有重要的临床意义。 为此，申请人提出了一项形态测量学研究，旨在 解开儿童BPD与ADHD的共病。四个样本， 由20名6-16岁的儿童组成，将被研究：1)儿童 对于ADHD和BPD，2)ADHD儿童，3)BPD儿童，4) 健康的志愿者。这项研究测试了四个相互竞争的假设，以确定 患有BPD和ADHD的儿童是否有形态测量结果 与ADHD儿童或儿童类似的临床相关性 患有BPD，或同时患有ADHD和BPD的儿童，或者如果他们有独特的 调查结果。如果得到资助，这项拟议的工作将填补研究中的两个空白 文献：这将是1)儿童BPD最大的神经影像研究 以及2)第一个检验关于这种关系的假说的核磁共振研究 在ADHD和BPD之间。通过揭示病因学的争论，这项工作 将对这些儿童的诊断和治疗产生影响。 此外，候选人还将接受儿童临床研究方法方面的培训 精神病学(20%的努力)在约瑟夫·比德曼的赞助下， 医学博士(共同导师)，哈佛医学院精神病学教授， Verne Cavness，医学博士(共同导师)，儿科神经病学教授 哈佛医学院，让她掌握了 儿童BPD的形态计量学研究，强调评估 儿童的精神病理和核磁共振扫描的评价。Dr。 精神病学副教授斯蒂芬·法劳内将担任 数据库管理和数据分析方面的顾问，以及 生物统计学课程中的正规教学培训(20%努力) 哈佛大学公共卫生学院。通过让应聘者集中时间 和精力来获得必要的技能，该奖项是重要的一步 在她的目标是在童年的神经成像方面进行独立研究 狂热。

DESCRIPTION (Adapted from Applicant's Abstract): The goal of this Mentored Clinical Scientist Development Award (K08) is to permit the Candidate to develop into an independent clinical investigator by pursuing a program of training and supervised clinical research in brain anatomic magnetic resonance imaging (MRI) of childhood bipolar disorder. Despite the well documented morbidity and dysfunction of childhood BPD, the disorder remains one of the most controversial topics in child psychopathology and as a consequence, among the least researched child psychiatric disorders. This controversy is largely nosological. There is no disagreement that these children exist. Yet, it is the absence of adequate scientific data on childhood BPD that has generated a vicious cycle of skepticism and absence of research. A leading factor that complicates the diagnosis of BPD in children is the frequent comorbidity with ADHD. The critical question is whether these children have ADHD, BPD or both disorders. The resolution of this question has important clinical implications. To this end, the applicant proposes a morphometric study aimed at disentangling the comorbidity of childhood BPD with ADHD. Four samples, consisting of twenty 6-16 year old children, will be studied: 1) children with both ADHD and BPD 2) children with ADHD, 3) children with BPD, and 4) healthy volunteers. The study tests four competing hypotheses to determine whether children with BPD+ADHD have morphometric findings, in conjunction with clinical correlates that are similar to children with ADHD, or children with BPD, or with children with both ADHD and BPD, or if they have unique findings. If funded, the proposed work will fill two gaps in the research literature: it will be 1) the largest neuroimaging study of childhood BPD and 2) the first MRI study that tests hypotheses about the relationship between ADHD and BPD. By shedding light on the nosologic debate, this work will have implications for the diagnosis and treatment of these children. In addition, the Candidate will train in Clinical Research Methods in Child Psychiatry (20 percent effort) under the sponsorship of Joseph Biederman, M.D. (co-mentor), Professor of Psychiatry at Harvard Medical School and Verne Caviness, M.D. (co-mentor), Professor of Pediatric Neurology at Harvard Medical School, allowing her to master the methodology of morphometric studies in childhood BPD, emphasizing the assessment of psychopathology in the children and the evaluation of their MRI scans. Dr. Stephen Faraone, Associate Professor of Psychiatry, will serve as a consultant regarding data base management and data analysis and regarding Formal Didactic Training (20 percent effort) in biostatistics courses at the Harvard School of Public Health. By allowing the Candidate to focus time and energy on acquiring the necessary skills, the Award is an important step in her goal to pursue independent research in neuroimaging of childhood mania.