GENETIC AND SOCIAL INFLUENCES ON YOUTH HEALTH BEHAVIORS

描述（改编自申请人的摘要）：本赠款申请是 临床科学家发展指导奖（KO 8） 主要 目的是提供PI，一个儿童精神病学家感兴趣的是 医学患病儿童的心理结果，技能和知识 成为遗传和环境领域的独立研究者 青年健康行为的决定因素。 这一长期方案目标 将通过这个奖项通过量身定制的培训计划和 研究情感性精神障碍与 青年哮喘 研究建议的具体目标是：1） 建立MZ中内化症状和哮喘症状的协方差 和DZ双胞胎对; 2）确定协方差的比例是由于 遗传（A），共享或非共享环境（E）因素; 3）建立 由于A、C和E输入导致的医疗保健行为的方差部分; 以及4）开发和统计测试模型来解释这些关系 情感和焦虑症状，健康行为和功能性哮喘 儿童和青少年的严重性。 将分三个阶段： 初步阶段，分析现有的双胞胎数据， 变量的相关性和指导最终样本招募策略; a 试点阶段，在此阶段，健康行为的措施在一个 哮喘样本;和最终实施，双胞胎将 招募和收集新的措施，为整个研究。 职业 发展计划是专门设计给主要的 研究者在以下方面的能力：1）统计建模策略; 2） 行为遗传学：3）父母和青少年健康行为的评价; 先进的数据精简、管理和分析策略 这一层次的研究所需的。 职业发展的方法 包括：1）建议的研究项目; 2）主要的导师制 博士休伊特; 3）UCHSC教师的其他成员的第二次导师制; 4)咨询儿童精神病理学领域的专家， 遗传学和健康行为; 5）正式课程; 6）正在进行的 行为遗传学研究所和 发展心理生物学研究小组; 7）参加科学研究 8）准备数据，以提交给专业人员 评审期刊。

DESCRIPTION (Adapted from applicant's abstract): This grant application is for the Mentored Clinical Scientist Development Award (KO8). The main objective is to provide the PI, a child psychiatrist interested in psychological outcomes of medically ill children, the skills and knowledge to be an independent researcher in the area of genetic and environmental determinants of health behaviors in youth. This long-term programmatic goal will be fostered through this award via a tailored training program and a specific research project examining the linkage of affective disorders and asthma in youth. The specific aims of the research proposal are to: 1) establish the covariance of internalizing symptoms and asthma symptoms in MZ and DZ twin pairs; 2) determine what proportion of the co-variance is due to genetic (A), shared or non-shared environmental (E) factors; 3) establish the portion of variance in health care behaviors due to A, C, and E inputs; and 4) develop and statistically test a model to explain the relationships of affective and anxiety symptoms, health behaviors, and functional asthma severity in children and adolescents. There will be three phases: a preliminary phase, in which existing twin data is analyzed to assess correlation of variables and guide final sample recruitment strategy; a pilot phase, in which measures of health behavior are piloted in an asthmatic sample; and final implementation, where twin pairs will be recruited and new measures collected for the full study. The Career Development Plan has been specifically designed to give the principal investigator competencies in: 1) statistical modeling strategies; 2) behavioral genetics; 3) assessment of health behaviors in parents and youth; and 4) the advanced data reduction, management, and analytic strategies required for this level of studies. The methods for career development include: 1) the proposed research projects; 2) the primary mentorship of Dr. Hewitt; 3) the second mentorship of other members of the UCHSC faculty; 4) consultations with experts in the fields of child psychopathology, genetics, and health behaviors; 5) formal coursework; 6) the ongoing training activities of the Institute for Behavioral Genetics and the Developmental Psychobiology Research Group; 7) attendance at scientific conferences; and 8) preparation of data for submission to professionally refereed journals.