SYMPTOM PERCEPTION IN CRITICAL ADOLESCENT ASTHMA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol seeks to understand one of the risk factors for asthma death, i.e., why some adolescents with asthma are unable to perceive changes in their respiratory symptoms. There is evidence that this decreased perception of changes in respiratory status is a risk factor for death or serious complications from asthma, but it is unknown whether the inability to perceive symptoms is due to an underlying neurophysiologic deficit, or whether it is due to psychological factors. Understanding the etiology of the problem is key to developing appropriate treatment and/or prevention strategies for those adolescents at risk. In this three site study, we anticipate studying 96 adolescents who have had a life threatening asthma episode (LTA), and we will compare them to two control groups that are matched on gender, age and ethnicity: a group with asthma, but no LTA, and group with no medical illnesses. We will determine each adolescents ability to detect changes in respiratory symptoms using three different paradigms. We will then examine basic neurophysiological sensory systems, as well as psychological factors, to see which are related to symptoms perception. Study in Data Analysis Only 05/