NOVEL APPROACH TO DELIVERING EXCIMER UV ENERGY FOR PRK

描述：(改编自《调查者摘要》)： 角膜切开术--屈光不正手术的主要方法 错误，有一个主要的弱点-无法准确地预测 个别病人的手术结果。准分子紫外线(UV) 如果将激光耦合起来，就能为这个问题提供潜在的解决方案 一种有效的激光传输系统。 准分子激光屈光性角膜切削术(PRK)或基于激光的角膜手术可以 可通过多种类型的激光传输配置来实施。这个 两种最成功的方法是虹膜扩张术，它提供了 一个简单的实现，但仅限于治疗近视，并且 提供最大治疗灵活性的扫描点技术 但治疗时间延长，输送硬件复杂。 Feo Medical建议为角膜提供复杂的矫正图案 使用一种基于 在数字微机械设备上，由640x480阵列组成 连接到数字角膜上的单独控制的微镜 地形系统。 在第一阶段，计算机生成的测试图案将被蚀刻到 各种紫外线敏感测试材料。由此产生的蚀刻图案将 与已知的模式进行比较，以衡量项目的成功 并为第二阶段的工作奠定基础，这将涉及动物 和人体研究。

DESCRIPTION: (Adapted From The Investigator's Abstract): Refractive keratotomy, the dominant method for surgical correction of refractive error, has one main weakness - the inability to predict accurately the outcome of surgery for an individual patient. Excimer ultraviolet (UV) lasers offer a potential solution to this problem if they are coupled to an effective laser delivery system. Photorefractive Keratectomy (PRK), or laser-based corneal surgery, can be implemented through many types of laser delivery configurations. The two most successful ones are the expanding iris technique, which offers a simple implementation but is limited to treating myopia, and the scanning spot technique which offers the greatest treatment flexibility but with extended treatment times and complicated delivery hardware. FEO Medical proposes to deliver complex correction patterns to the cornea in substantially reduced treatment times using a novel technique based on a digital, micromachined device, consisting of a 640x480 array of individually- controlled micromirrors, coupled to a digital corneal topography system. During Phase I, computer-generated test patterns will be etched onto various UV-sensitive test materials. The resulting etch patterns will be compared to the known patterns to measure the success of the project and establish a basis for the Phase II effort which will involve animal and human studies.