TRAINING GRANT IN MECHANISMS OF VASCULAR DISEASE

血管疾病机制培训计划的更新将把范德比尔特大学和梅哈里医学院在血管生物学方面的多部门研究的相当大的优势和多样性集中在一个连贯的专门培训框架中。参与的系包括范德比尔特的生物化学、生物医学工程、细胞生物学、微生物学和免疫学、分子生理学和生物物理学、病理学、药理学、化学和两个临床系(医学和儿科)，以及梅哈里的微生物学。将提供七个专门研究领域的培训：(1)蛋白质化学和酶学；(2)生长因子调节/发展；(3)细胞外基质生物学；(4)内皮细胞生物学；(5)脂蛋白代谢和动脉粥样硬化；(6)心血管调节；(7)白细胞/红细胞生物学。每个项目将由4-7名积极从事血管生物学相关方面研究的研究人员组成。该计划将为8名博士后、6名博士后(医学博士和/或博士)提供津贴。博士前培训将导致获得一个基础科学学科的学位，并将通过中央研究生招生计划和目前在医学院实施的核心课程得到加强，分子生物学系参与其中。论文研究将与该项目的一名教员一起从事与血管生物学相关的专业领域之一。博士后培训将主要包括在一名教师导师的指导下进行实验室研究。博士后和博士后实习生都将被要求参加由参与教师讲授的课程，血管疾病的细胞和分子基础，以及其他课程，具体取决于候选人的背景。学员还将参加血管生物学和正在进行的工作研讨会，以及选定的部门研究研讨会。拥有医学博士学位的实习生可以在基础科学学科中寻求博士学位。预计学员未来将在血管生物学的某些领域从事教学和研究工作。培训设施包括范德比尔特的5栋毗邻的研究大楼和梅哈里的微生物学系，它们是教官的研究实验室。参与的教职员工的实验室里有充足的空间和最先进的仪器。对未来这一领域的研究科学家进行多学科研究培训，预计将对发现新信息至关重要，这些信息将导致改善心血管疾病的诊断、预防和治疗。

The renewal of the Training Program in Mechanisms of Vascular Disease will focus the considerable strengths and diversity of multi- departmental research in vascular biology at Vanderbilt University and Meharry Medical College into a coherent framework for specialized training. Participating departments include Biochemistry, Biomedical Engineering, Cell Biology, Microbiology & Immunology, Molecular Physiology & Biophysics, Pathology, Pharmacology, Chemistry and two clinical departments (Medicine and Pediatrics) at Vanderbilt, and Microbiology at Meharry. Training will be offered in seven specialized areas of research: (1) Protein chemistry and enzymology; (2) Growth factor regulation/development; (3) Biology of the extracellular matrix; (4) Endothelial cell biology; (5) Lipoprotein metabolism and atherosclerosis; (6) Cardiovascular regulation, and (7) Leukocyte/red cell biology. Each program will be composed of 4-7 investigators actively pursuing research on related aspects of vascular biology. The program will support stipends for 8 predoctoral, 6 postdoctoral (M.D. and/or Ph.D.). Predoctoral training will lead to a degree in one of the basic science disciplines and will be enhanced by the central program for graduate student recruitment and the core curriculum currently in effect in the School of Medicine with participation by the Department of Molecular Biology. Thesis research will bone in one of the specialized areas related to vascular biology with one of the faculty of this program. Postdoctoral training will consist primarily of laboratory research under the guidance of a faculty supervisor. Both predoctoral and postdoctoral trainees will be required to participate in the course, Cellular and Molecular Basis of Vascular Disease, taught by the participating faculty, and other courses depending on the background of the candidate. Trainees will also attend and participate in the Vascular Biology and Work-in-Progress Seminars and selected departmental research seminars. Trainees with an M.D. degree may seek a Ph.D. degree in one of the basic science disciplines. It is expected that the trainee will the future pursue teaching and research careers in some area of vascular biology. Training facilities include 5 adjacent research buildings at Vanderbilt and the Department of Microbiology at Meharry which house the research laboratories of the preceptors. Ample space and state-of-the- art instrumentation are available in the laboratories of the participating faculty. Multi-disciplinary research training of future research scientists in this area is expected to be critical to discovering the new information that will lead to improved diagnosis, prevention and therapy for cardiovascular diseases.