Determinants and Mechanisms Involved in Alcohol Consumption and its Health Consequences

在目前提出的研究中，我将使用来自英国生物银行的遗传、环境和代谢物数据、无线健康监测研究和已发表的全基因组关联研究以及动物模型，以突出涉及饮酒和相关疾病的决定因素、机制和途径。我将使用英国生物银行的数据来研究饮酒的风险因素和决定因素，以及饮酒引起的疾病。通过使用Airwave研究中的酒精消费数据和代谢物，我将确定与酒精相关代谢物相关的基因。然后，我将在英国生物银行的研究中测试酒精代谢物基因，以突出通过饮酒与肝脏脂肪积累有关的途径。我还将测试动物模型，以确定基因和饮酒之间关系背后的潜在生物学原理。

In the current proposed research, I will be using genetic, environmental and metabolite data from the UK Biobank, the Airwave health monitoring study and published genome-wide association studies as well as animal models in order to highlight determinants, mechanisms and pathways involved in alcohol consumption and related diseases. I will use UK Biobank data to study risk factors and determinants of alcohol consumption as well as diseases caused by alcohol consumption. By using alcohol consumption data and metabolites in the Airwave study, I will identify genes that are linked to alcohol-related metabolites. I will then test alcohol-metabolite genes in the UK Biobank study to highlight pathways that are linked to fat accumulation in liver via alcohol consumption. I will additionally test animal models to identify the underlying biology behind the association of genes and alcohol consumption.