MECHANISM OF REGULATION OF NV-KB

科学价值;拟议研究的目标是阐明 参与转录激活的信号机制 NF-κ B因子。 NF-kB是一种诱导因子， 通过抑制蛋白IkB在细胞质中表达。 细胞暴露于 适当的刺激导致快速磷酸化， IkB降解，导致NF-κ B易位至细胞核， 参与基因转录的激活。 候选 提出要确定蛋白激酶，负责 磷酸化IkB，然后研究这种激活的机制。 激酶。 作为一个长期目标，他将尝试追踪信号 NF-kB的转导途径回到细胞表面受体。

Scientific Merit; The goal of the proposed studies is to elucidate the signalling mechanisms involved in the activation of the transcription factor NF-kB. NF-kB is an inducible factor that is held in an inactive state i the cytoplasm by the inhibitory protein IkB. Exposure of cells to appropriate stimuli results in rapid phosphorylation and subsequent degradation of IkB with a resulting translocation of NF-kB to the nucleus, where it is involved in activation of gene transcription. The candidate proposes to identify the protein kinase that is responsible for phosphorylating IkB and then to study the mechanism of activation of this kinase. As a longer term goal, he will attempt to trace the signal transduction pathways for NF-kB back to cell surface receptors.