BIOMARKERS OF LUNG CANCER SUSCEPTIBILITY IN MINORITIES

描述：（改编自研究者摘要）肺癌是 是美国癌症死亡率的主要原因。 种族差异 对肺癌发生率和存活率了解不足， 反映了环境和基因的影响。 阐明 这些因素在极高和极低风险人群中的相互作用将 在制定新的干预和预防战略方面至关重要。 这 一项研究的重点是非洲裔美国人谁承担了不成比例的负担， 肺癌和拉美裔的发病率非常低。 调查人员表示， 这是他们在休斯顿进行的肺癌生态遗传学研究的延续， 德克萨斯州，将测试从第一次研究的具体结果在一个大的人口 北方加州的非洲裔美国人和拉丁裔美国人， 在少数民族中从未研究过的基因位点。 他们会收集血液 标本，并对每个族裔的350例病例进行面对面访谈 通过北方加州癌症中心（NCCC）快速鉴定 案例确定程序，以及同等数量的种族，年龄， 通过随机数字拨号招募性别频率匹配的对照。 他们 将建立一个DNA库，估计遗传病的流行程度， 细胞色素P-450基因（CYP 1A 1）多态性，两种谷胱甘肽 S-转移酶（GSTM 1，GSTT 1），NAD（P）H：醌氧化还原酶（NQ 01）和 两种N-乙酰基转移酶（NAT 1，NAT 2）和XRCC 1 DNA修复基因。 的 研究人员指出，这些特征与肺的先前关联， 高加索人或日本人的癌症不容易推广到 少数民族没有进一步的详细研究，他们建议在这里。 使用 多个遗传标记是同时检测 关于基因对癌症风险的贡献的几种假设。 他们 进一步指出，一个特别独特的贡献将奠定 肺癌的发病率明显较低， 拉丁裔人口;他们强调，他们的研究代表了唯一的 在拉丁美洲人中进行的基于人口的研究。 此外，他们指出， 这将是第二个基于人群的遗传流行病学 非裔美国人肺癌研究; 加州人一生中患肺癌的风险为11%。 进一步指出， DNA库和关于吸烟和其他问题综合问卷数据 重要的风险因素也将证明是非常宝贵的， 肺癌的遗传流行病学

DESCRIPTION: (Adapted from Investigator's Abstract) Lung cancer is the leading cause of cancer mortality in the United States. Ethnic differences in lung cancer occurrence and survival are inadequately understood and may reflect both environmental and genetic influences. Elucidating the interplay of these factors in very high- and very low-risk populations will be crucial in developing novel intervention and prevention strategies. This study focuses on African-Americans who bear a disproportionate burden of lung cancer and Latinos who have very low rates. The investigators state that this continuation of their ecogenetics study of lung cancer in Houston, TX, will test specific findings from the first study in a large population of African-Americans and Latinos in Northern California and will explore gene loci never before studied in minorities. They will collect blood specimens and conduct in-person interviews with 350 cases from each ethnic group, identified through the Northern California Cancer Center (NCCC) rapid case ascertainment program, and an equal number of ethnicity-, age-, and sex-frequency matched controls recruited through random digit dialing. They will establish a DNA bank and estimate the prevalence of genetic polymorphisms in a cytochrome P-450 gene (CYP1A1), two glutathione S-transferases (GSTM1, GSTT1), the NAD(P)H:quinone oxidoreductase (NQ01) and two N-acetyl transferases (NAT1, NAT2), and the XRCC1 DNA repair gene. The investigators state that previous associations of these traits with lung cancer among Caucasians or Japanese are not readily generalizable to minorities without the further detailed study that they propose here. Using multiple genetic markers is a highly efficient means to simultaneously test several hypotheses concerning genetic contributions to cancer risk. They further state that an especially unique contribution will be laying the foundation to understand the markedly lower rates of lung cancer among Latino populations; they emphasize that their study represents the only population-based study of its kind among Latinos. Furthermore, they state that this will be only the second population-based genetic epidemiologic study of lung cancer in African-Americans; African-American men in California have an 11% lifetime risk of lung cancer. The further note that the DNA bank and comprehensive questionnaire data on smoking and other important risk factors also will prove invaluable for continuing studies of the genetic epidemiology of lung cancer.