SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT)

项目2（SPECT）将检查计算的单光子发射 两组受试者的断层扫描（SPECT）数据，以便 确定阿尔茨海默病发展的早期预测因素 疾病（AD）。 第一组受试者（队列1）由以下人员组成： 上一个供资周期征聘和跟踪的个人 （n=165）。 第二个样本（队列2）将在 下一个供资周期（n=106）。 两个队列均由对照组组成 (CDR=0）和“可疑”AD受试者（CDR=0.05）。 项目 2将收集这些参与者的数据，以确定SPECT 预测哪些受试者会在以后发展到 符合AD的标准 项目2的数据也将 结合其他项目和核心的数据， 来自所有感兴趣的主要领域的变量（例如， 神经心理学，SPECT，fMR，遗传学等），最好地预测 AD的发展。

Project 2 (SPECT) will examine single photon emission computed tomography (SPECT) data in two cohorts of subjects, in order to identify early predictive factors for the development of Alzheimer's disease (AD). The first group of subjects (Cohort 1) consists of those individuals recruited and followed during the last funding cycle (n=165). A second sample (Cohort 2) will be recruited during the next funding cycle (n=106). Both cohorts consist of controls (CDR=0) and subjects with "questionable" AD (CDR=0.05). Project 2 will gather data on these participants in order to identify SPECT variables that predict which subjects will later progress to the point where they meet criteria for AD. Data from Project 2 will also be combined with data from other projects and Cores to determine the variables from all of the major domains of interest (e.e., neuropsychology, SPECT, fMR, genetics, etc) that best predict the development of AD.