NIMH CENTER FOR GENETIC STUDIES

遗传因素在重病家族聚集性中的作用 大脑障碍得到了很好的支持。NIMH人类遗传学倡议 (http://www-grb.nimh.nih.gov/gi.html)支持多学科和 合作研究项目，采用最先进的技术 诊断程序和分析方法，以收集大样本 用于精神分裂症和心境遗传分析的家系 精神错乱。全面的临床数据和生物材料收集于 NIMH将向符合条件的人员广泛提供此计划 基因分析科学界的研究人员 目的鉴定与这些疾病易感的基因。 这份合同的主要目标是建立NIMH中心 遗传研究，这将完成以下工作：(1)获得 临床、诊断、家系结构和其他数据和血液 来自NIMH支持的人类遗传学项目的样本，将 确定有多个个体受感染的家系 精神分裂症、情绪障碍或其他精神障碍；(2)过程 创建表型信息电子数据库以供使用的数据 在遗传分析中；(3)从接受的血液中转化淋巴细胞 用于创造高质量细胞系的样本，DNA将从这些细胞系中提取 提取；(4)将这些数据和生物材料与 NIMH人类遗传学中可比较的现有数据和生物材料 倡议；(5)接收从遗传分析中获得的数据 生物材料在人类遗传学倡议中的作用；和(6)广泛 分发所有表型和遗传型数据以及生物材料 (细胞系和DNA样本)，在NIMH人类遗传学倡议中 科学界有资质的调查人员。

The role of genetic factors in the familial aggregation of serious brain disorders is well supported. The NIMH Human Genetics Initiative (http://www-grb.nimh.nih.gov/gi.html) supports multidisciplinary and collaborative research projects, employing state-of-the-art diagnostic procedures and analytic methods, to collect large samples of pedigrees for genetic analyses of schizophrenia and mood disorders. Comprehensive clinical data and biomaterials collected in this Initiative will be made widely available by NIMH to qualified investigators in the scientific community for genetic analyses that aim to identify genes conferring susceptibility to these disorders. The main objective of this contract is to establish the NIMH Center for Genetic Studies, which will accomplish the following: (1) receive clinical, diagnostic, pedigree structure, and other data and blood samples from NIMH-supported human genetics projects, which will ascertain pedigrees with multiple individuals affected with schizophrenia, mood disorders, or other mental disorders; (2) process data to create electronic databases of phenotypic information for use in genetic analyses; (3) transform lymphocytes from received blood samples to create high-quality cell lines, from which DNA will be extracted; (4) incorporate these data and biomaterials with comparable existing data and biomaterials in the NIMH Human Genetics Initiative; (5) receive data derived from genetic analyses of biomaterials in the Human Genetics Initiative; and (6) widely distribute all phenotypic and genotypic data, as well as biomaterials (cell lines and DNA samples), in the NIMH Human Genetics Initiative to qualified investigators in the scientific community.