CORE--PEPTIDE SYNTHESIS, PURIFICATION, FOLDING AND STRUCTURAL ANALYSIS FACILITY

Core负责制备各种多肽。蛋白蛋白通常由韦林博士在加州大学洛杉矶分校合成。LL-37和相关的α -螺旋肽将由埃默里大学的波尔博士合成，任何受益于t-boc合成的蛋白也将由波尔博士合成。高质量肽的可用性对于拟议的研究是绝对必要的。Waring博士和Pohl博士是非常有成就的研究者，拥有最先进的肽合成、纯化和表征工具。

Core is responsible for preparing the various peptides. Protegrins will generally be synthesized by Dr. Waring at the UCLA site. LL-37 and related alpha-helical peptides will be synthesized by Dr. Pohl at Emory, as will any protegrins that would be benefit from t-boc synthesis. The availability of high-quality peptides is absolutely essential for the proposed studies. Dr. Waring and Pohl are highly accomplished investigators with access to state-of-the-art tools for peptide synthesis, purification and characterization.