LONGITUDINAL ADOPTION STUDY OF ADOLESCENT SUBSTANCE EXPERIMENTATION

这项建议的主要目标是评估遗传和 环境对烟草、酒精、 大麻等毒品采用纵向采用设计。这 这项研究建立在20多年来收集的数据基础上，作为 科罗拉多州收养项目(CAP)，并专注于传播 物质使用和行为障碍等先天行为 症状、其他行为问题和学习成绩 困难。作为另外两项措施的一部分而收集的措施的紧密结合 此中心应用程序的组件，组件2(青少年 物质滥用)和组成部分4(青少年双胞胎)将促进 物质使用与相关行为的交叉成分分析 有问题。对来自该组件和组件的数据进行组合分析 2将明确检验家族性传播参数假设 对于严重的药物滥用和青春期的实验是 截然不同。来自该组件和组件4的数据的组合分析 将测试特定双胞胎共享环境的重要性 参数，该参数包括队列效果。 到赠款周期结束时，物质实验历史 到17岁将从200多个被领养的人中获得 先证者和100名在基因上没有血缘关系的年长兄弟姐妹和200名配对 控制早熟。此外，每种类型的90个弟弟妹妹 将至少被纵向跟踪到15岁。一些人 关于儿童的生物父母和养育父母使用物质的信息 先驱们目前可用；有关实质性的补充信息 领养和对照先证者的养育父母将使用 收好了。关于气质，个性，认知能力的信息， 成就和调整，以及个人对 家庭环境，适用于所有CAP参与者。多变量 对组合数据集的遗传分析也将用于测试 关于遗传和环境调节的假说 行为问题、物质实验和 成就。

The primary objective of this proposal is to assess genetic and environmental influences on experimentation with tobacco, alcohol, marijuana, and other drugs using a longitudinal adoption design. This study builds on more than 20 years of data collected as part of the Colorado Adoption Project (CAP), and focuses on the transmission of substance use and antecedent behaviors such as conduct disorder symptoms, other behavioral problems, and academic achievement difficulties. Close integration of measures collected as part of two other components from this center application, Component 2 (Adolescent Substance Abuse), and Component 4 (Adolescent Twins), will facilitate cross-component analysis of substance use and related behavioral problems. Combined analysis of data from this component and component 2 will explicitly test the hypothesis that familial transmission parameters for severe substance abuse and for experimentation in adolescence are distinct. Combined analysis of data from this component and component 4 will test the importance of a specific twin shared environmental parameter that includes cohort effects. By the end of the grant cycle, substance experimentation histories through age 17 will have been obtained from more than 200 adopted probands and 100 genetically unrelated older siblings and 200 matched control early adulthood. In addition, 90 younger siblings of each type will have been followed longitudinally at least to age 15. Some information on substance use by the biological and rearing parents of the probands is currently available; additional information on substance use by rearing parents of the adopted and control probands will be collected. Information on temperament, personality, cognitive abilities, achievement, and adjustment, as well as individual perceptions of the family environment, is available for all CAP participants. Multivariate genetic analyses of combined data sets will also be used to test hypotheses concerning genetic and environmental mediation of the association between behavioral problems, substance experimentation, and achievement.