Development of gene-activated scaffolds as bone bioreactor for bone regeneration and osteointegration

骨替代品的全球市场估计每年超过10亿美元。新兴的细胞治疗技术为骨缺损的治疗打开了一扇新的窗口。本项目旨在开发基因激活支架，诱导血管形成，改善局部营养供应，进而刺激骨缺损处的骨形成，促进种植体表面周围的骨整合。从这个项目中产生的知识将有助于治疗许多骨科和牙科疾病。

The worldwide market for bone substitutes has been estimated at over US $1 billion annually. The emerging technology of cell based therapy has opened a new window for the treatment of bone defects. This project is to develop gene-activated scaffolds able to induce blood vessel formation thus improving the local nutrition supply, and subsequently stimulating bone formation in bone defects, as well as osteointegration around implant surface. The knowledge generated from this project will help the treatment of a number of orthopaedic and dental conditions.