ANATOMY OF NEUROENDOCRINE PEPTIDE PATHWAYS IN BRAIN

描述：（直接从应用程序中获取）。促肾上腺皮质激素- 刺激垂体肾上腺对压力的反应 CRF还广泛 垂体肾上腺对压力的反应CRF也广泛表达于 互补的自主和行为机制， 自动和行为机制，通常在以下情况下调用 功能性CRF受体（CRF-R）的表达提供了一个关键工具， 功能性CRF受体（CRF-R）提供了一种关键工具， 垂体中的分布与主要神经内分泌完全一致 垂体中的分布与主要的 包含突出物，特别是在涉及应力的区域中， 包括通用报告格式的预测，特别是在涉及 识别并提供区域的功能解剖背景 旨在识别和提供功能解剖背景， 关于如何调和各区域差异的备选假设 寻求替代假设，以了解差异如何可能是 和电子显微镜水平来表征细胞和亚细胞 将在光学和电子显微镜水平上用于表征 垂体促肾上腺皮质激素。 双重染色方法将评估 脑内CRF和垂体促肾上腺皮质激素的变化。双重染色 与突触后膜特化并列，CRF-R-ir是 终末可与突触后膜突触并列 mRNA和/或蛋白质表达将被用来确定首先如何 感兴趣的区域。mRNA和/或蛋白质的各种原位测定 环境，调节CRF表达的主要因素内外 皮质类固醇环境中的压力和扰动主要 在脑和垂体中的CRF靶细胞中进行处理， 下丘脑CRF-R被隔离和处理的方式 将探讨在光和电子显微镜水平下的基础 另一种高亲和力CRF结合部分CRF结合蛋白将 杂交组织化学方法，如刚刚描述的那些， 挑战条件。最后，我们将采用免疫和杂交 通过CRF-R的新配体和/或CRF-R的存在来调节， 明显配体-受体错配的主要区域可通过 处理变体或子类型。滴度变化和/或 下丘脑外CRF可导致库欣样或艾迪生症状， 对库欣样或艾迪生症状的敏感性改变， 情感障碍如神经性厌食症和重度抑郁症 神经性厌食症和严重抑郁症等疾病。集体 CRF信号传导的神经内分泌和神经生物学背景. CRF在多个水平上的信号传导的神经生物学背景 压力相关神经和神经内分泌系统。

Description: (Taken directly from the application). Corticotropin- driving pituitary-adrenal responses to stress. CRF is also widely pituitary-adrenal responses to stress. CRF is also widely expressed in complementary autonomic and behavioral mechanisms that are commonly invoked autonomic and behavioral mechanisms that are commonly invoked following of a functional CRF receptor (CRF-R) provides a critical tool with which to a functional CRF receptor (CRF-R) provides a critical tool with which distribution in pituitary is fully compatible with the major neuroendocrine distribution in pituitary is fully compatible with the major containing projections, particularly in regions implicated as stress- of CRF-containing projections particularly in regions implicated as identifying, and providing a functional anatomical context, for areas in aimed at identifying and providing a functional anatomical context for alternative hypotheses as to how discrepancies may be reconciled in regions to pursue alternative hypotheses as to how discrepancies may be and electron microscopic level to characterize the cellular and subcellular will be used at the light and electron microscopic level to characterize corticotropin in pituitary. Dual staining approaches will assess those of CRF in brain and of corticotropin in pituitary. Dual staining apposed to postsynaptic membrane specializations with which CRF-R-ir is terminals may be synaptically apposed to postsynaptic membrane of mRNA and/or protein expression will be employed to determine first how regions of interest. Various in situ assays of mRNA and/or protein environment, the major factors modulating CRF expression within and beyond stress and perturbations in the corticosteroid environment the major processed in CRF target cells in brain and pituitary that do and do not hypothalamus. The manner in which CRF-R is sequestered and processed in will be explored at the light and electron microscopic levels under basal another high-affinity CRF-binding moiety the CRF- binding protein will hybridization histochemical approaches like those just described to challenged conditions. Finally we will employ immuno- and hybridization accommodated by novel ligands for the CRF-R and/or the existence of major areas of apparent ligand-receptor mismatch may be accommodated by processing variants or subtypes. Alterations in titers and/or extrahypothalamic CRF can lead to Cushingoid or Addisonian symptoms, to Cushingoid or Addisonian symptoms modified susceptibility to immune the etiology of affective disorders such as anorexia nervosa and major disorders such as anorexia nervosa and major depression. Collectively neuroendocrine and neurobiological contexts for signaling by CRF at neurobiological contexts for signaling by CRF at multiple levels of stress-related neuronal and neuroendocrine systems.