Gene-environment interactions in the regulation of neuroplasticity and cognitive function

该项目将通过结合创新的操作性条件反射行为测试（计算机化触摸屏技术）和新的分子方法，研究不同住房条件对神经可塑性相关认知功能的影响。潜在的基因-环境相互作用将使用从未在该背景下评估过的基因靶向小鼠（糖皮质激素和5-羟色胺信号传导改变的突变体）来揭示。该项目将研究神经可塑性过程的特定阶段是否通过基因-环境相互作用进行差异调节，最终导致行为和认知功能的变化。这将导致更好地了解可用于改善认知功能的潜在方法。

This project will study the effects of different housing conditions on neuroplasticity-related cognitive function by combining an innovative operant conditioning behavioural test (computerised touch-screen technology) and new molecular approaches. Potential gene-environment interactions will be revealed using genetically targeted mice which have never been assessed in that context (mutants with altered glucocorticoid and serotonin signalling). This project will study whether specific stages of the neuroplasticity process are differentially modulated through gene-environment interactions, ultimately resulting in changes to behaviour and cognitive functions. This will lead to a better understanding of the potential approaches that could be used to improve cognitive function.