MOLECULAR APPROACHES TO PEDIATRIC SCIENCE - CHRC

这是The Children's的竞争性续约申请 费城医院（CHOP）MAPS/CHRC补助金。在过去， 期间，我们支持了16个MAPS的分子研究培训和研究 从儿科奖学金到教师过渡期间的学者 任命（共24年的供资）。于编制日期 在这次更新申请（11/96）中，这16人中的每一个都持有学术学位， 在儿科的任命，12已经 成功地获得额外的校外研究支持，包括 2个RO 1，2个R29，5个K 08和一个RW约翰逊少数民族学院K 08。的 4名尚未获得额外校外研究支助的人员， 五个月前成为MAPS学者。 我们的MAPS/CHRC主要基于CHOP Abramson研究 大楼，一个设施提供138,000平方英尺的湿实验室空间。的 CHOP MAPS/CHRC分子核心在这座大楼里，实验室也在这里。 28名常设调查员中的23名将为以下人员提供指导： 我们的地图学者我们还联系了 宾夕法尼亚州（P的U），紧邻CHOP，为建立 研究人员-1名在Wistar研究所，2名在休斯研究所， 2在P医学院基础科学部门的U。 我们的更新申请要求新计划开发资金， 每年支持5名MAPS学者。为了放大这种影响， 重要项目，CHOP将放弃所有间接成本回收，并将 将MAPS/CHRC支持与为MAPS学者提供的分子核心相匹配 使用.此外，与上一个赠款期间一样， 宾夕法尼亚大学的儿科将在内部提供 产生资金，以大大补充MAPS/CHRC新方案 发展基金，以使我们能够选择和支持一个大的 我们优秀的MAPS奖学金申请人池的比例。

This is the competitive renewal application of The Children's Hospital of Philadelphia (CHOP) MAPS/CHRC Grant. During the past granting period, we supported molecular research training and research of 16 MAPS Scholars during their transition from pediatric fellowship to faculty appointments (a total of 24 years on funding). At the date of preparation of this renewal application (11/96), each of these 16 holds an academic appointment in a department of pediatrics, and 12 have already been successful in obtaining additional extramural research support, including 2RO1s, 2 R29s, 5K08s, and a RW Johnson Minority Faculty K08 equivalent. Of the 4 who have not yet received additional extramural research support, 3 became MAPS Scholars only 5 months ago. Our MAPS/CHRC is based largely in the CHOP Abramson Research Building, a facility providing 138,000 square feet of wet lab space. The CHOP MAPS/CHRC Molecular Core is in this building, as are the laboratories of 23 of the 28 Established Investigators who will provide mentoring to our MAPS Scholars. We have also reached out to the University of Pennsylvania (U of P), immediately adjacent to CHOP, for Established Investigators--1 at the Wistar Institute, 2 at the Hughes Institute, and 2 in U of P Medical School basic science departments. Our renewal application requests New Program Development funds to support 5 MAPS Scholars/year. In order to amplify the effects of this important program, CHOP will waive all indirect cost recovery, and will match MAPS/CHRC support to the Molecular Core provided for MAPS Scholar usage. In addition, as during the previous granting period, the Department of Pediatrics of the University of Pennsylvania will provide internally generated funds to substantially supplement MAPS/CHRC New Program Development funds, in order to permit us to select and support a large proportion of our outstanding pool of MAPS Scholarship applicants.