PURCHASE OF A GAS CHROMOTOGRAPH MASS SPECTROMETER

该提案要求为气相色谱质谱仪提供资金， 光谱仪 扩大新闻部的用户群 化学在加州大学欧文分校，通过招聘 高级和初级教师和研究项目的发展 其中对增加样本量 容量和实时答案表明了这一迫切需要 用于获得无法获得的重要分析数据的仪器 通过其他技术。 UCI质谱仪设备包括： 两个磁扇区仪器的完全饱和， 合成程序的分析支持（精确质量测定）， 其他问题的解决，特别是使用LSIMS，直接探头和FD。 主要用户的研究项目包括：（a）SHEA，（B）Overman- 发现新的反应和策略以及合成配合物 分子，特别是通过多个立体特异性环的形成， (c)Rychnovsky-结构测定和收敛合成 多烯大环内酯类抗生素，手性氮氧自由基， 氧化催化剂;（d）货车中的Van Vranken-脱芳构化反应 通过芳香族[2，3]-Witting反应研究的化学体系 以及Sommelet-Hauser和thia-Sommelet的不对称版本 使用2，6-二取代的芳族化合物的反应;（e）Woerpel-立体特异性 特别涉及插入硅杂环丙烷的合成， α-烷氧基烯丙基硅烷的重排，烯醇化锂化学 和钯催化的偶联反应。 除了主要用户 还有其他NIH资助的研究小组， 需要GC-MS能力。仪表应配备用于EI 和CI，这两者对于获得结构性 信息. 此外，通过使用自动进样器和适当的 计算能力，仪器将被格式化为有限的数量 研究生用户，因此，将能够提供 将仪器留在水下时所需的旋转类型 经验丰富的质谱师的控制，设备主管 拥有超过20年的经验，其中大部分使用GC-MS。UCI拥有 对质谱仪设施的长期主要供资承诺， 以及其他分析光谱仪器设备 来支持研究人员。 目前，年度承诺为 近50万美元用于这些设施的工资和运营 支持. 额外的业务资金是通过向 用户社区的赠款和合同。

This proposal requests funding for a gas chromatograph-mass spectrometer. Expansion of the user community in the Department of Chemistry at the University of California, Irvine, through recruitment of senior and junior faculty and a the development of research projects in which there are specific requirements for both increased sample capacity and real-time answers demonstrate the urgent need for this instrumentation to obtain vital analytical data that cannot be obtained by other techniques. The UCI mass spectrometry facility which comprises of two magnetic sector instruments is fully saturated providing analytical support for synthetic program (exact mass determinations) and other problem solving, particularly using LSIMS, direct probe and FD. Research projects of the major users include: (a) SHEA, (b) Overman- discovery of new reactions and strategies and the synthesis of complex molecules, particularly through multiple stereospecific ring formation, (c) Rychnovsky- structure determination and convergent synthesis of polyene macrolide antibiotics, chiral nitroxides as enantioselective oxidation catalysts; (d) Van Vranken-dearomatization reactions in chemical systems investigated via the aromatic [2,3]-Witting reaction and asymmetric versions of the Sommelet-Hauser and thia-Sommelet reaction using 2,6-disubstituted aromatics; (e) Woerpel-stereospecific synthesis particularly involving insertions into silacyclopropanes, rearrangements of alpha-alkoxyallylsilanes, lithium enolate chemistry and palladium catalyzed coupling reactions. Aside from the major user group there are may other NIH funded research groups who urgently require GC-MS capability. The instrumentation is to be equipped for EI and CI, both of which are essential for obtaining structural information. In addition, by using an autosampler and appropriate computing capacity the instrument will be formatted for a limited number of graduate student users and will, therefore, be able to provide the type of turn around that is needed while leaving the instrument under the control of experienced mass spectroscopists, the facility director has over 20 years experience much of it utilizing GC-MS. UCI has a long-term major funding commitment to the mass spectrometry facility as well as the other analytical spectroscopy instrumentation facilities which support the research faculty. Currently the annual commitment is almost 500,000 dollars to these facilities in salaries and operational support. Additional operational funding is obtained though charges to the grants and contracts of the user community.