NEUROPSYCHOLOGICAL EVALUATION OF PSYCHIATRIC AND NEUROLOGICAL PATIENTS

在过去两年中，这项工作的主旨涉及 精神分裂症患者神经心理测试结果的比较 癫痫发作障碍(全身性和局灶性)与其 一级亲属。在早先对12个有先证者的家庭的研究中 诊断为儿童失神癫痫(CAE)，结果表明 患者的母亲，而不是父亲，以温和的形式分享 先证者的一些行为障碍(Levav，1991)。 这在持续注意力的测试中是显而易见的(持续的 性能测试，CPT；Rosvold等人，1956年)。这一结果是一致的。 与先前对该病遗传的研究相一致。 在目前的研究中，我们评估了先证者及其健康的一级水平。 亲属，以及健康的对照对，在他们的 神经心理测试。我们用以下方法评估先证者-亲属对 青少年肌阵挛癫痫(JME)、颞叶癫痫(TLE)和 儿童失神癫痫(CAE)。注意力、记忆力和问题解决 对行为进行研究，以评估可能的家族聚集性 认知特征。到目前为止的分析表明，存在一个 与控制有关的性状的强烈家族聚集性 持续注意任务中的冲动性和警觉性，尤其是在 JME家族。

During the past two years, the main thrust of this work has involved a comparison of the neuropsychological test profiles of patients with seizure disorders (generalized as well as focal) with those of their first-degree relatives. In an earlier study of 12 families with probands diagnosed with childhood absence epilepsy (CAE), the results indicated that the mothers, but not the fathers of the patients share in mild form some of the behavioral impairment seen in the probands (Levav, 1991). This was evident in tests of sustained attention (the Continuous Performance Test, CPT; Rosvold et al.,1956). This result is consistent with prior research on the inheritance of the disorder. In the present study we assessed probands and their healthy first degree relatives, as well as healthy control pairs, in their performance on neuropsychological tests. We assessed proband-relative pairs with Juvenile Myoclonic Epilepsy (JME), Temporal Lobe Epilepsy (TLE) and Childhood Absence Epilepsy (CAE). Attention, memory and problem-solving behavior were studied in order to evaluate possible familial aggregation of cognitive traits. The analysis thus far indicates that there is a strong familial aggregation of traits associated with control of impulsivity and vigilance in the sustained attention tasks, especially in the JME families.