MOLECULAR GENETIC ANALYSIS OF THE PRP GENE IN ANIMAL SPECIES SUSCEPTIBLE TO TSES

骡鹿和落基山脉麋鹿患上慢性疾病 属于传染性疾病组的消耗性疾病 海绵状脑病(TSE)。PrP基因编码区 已经在骡鹿和落基山脉麋鹿身上进行了分析。这个 预测的PrP氨基酸序列基本一致(99.6%)。 在两个物种之间，仅在第226密码子上存在单一差异 (分别为谷氨酰胺和谷氨酸)。基因的多态 在马鹿体内检测到第138密码子(丝氨酸到天冬酰胺)。 PrP基因编码区。进一步调查正在进行中，以 确定这种多态是否在骡子的易感性中起作用 鹿得了慢性消耗性疾病。对300次传输数据的分析 非人灵长类动物的不同形式的TSE揭示了恒河猴 猴子的传播成功率最低。分析 PRNP基因已经被用来阐明遗传基因的作用 恒河猴对流行性感冒易感性的影响因素。

Mule deer and Rocky Mountain elk develop chronic wasting disease that belongs to the group of transmissible spongiform encephalopathies (TSEs). The PrP gene coding region has been analyzed in mule deer and Rocky Mountain elk. The predicted amino acid sequence of PrP was nearly identical (99.6%) between two species, with only a single difference at codon 226 (glutamine and glutamic acid, respectively). A polymorphism at codon 138 (serine to asparagine) has been detected in mule deer PrP gene coding region. Further investigation is underway to establish if this polymorphism plays a role in susceptibility of mule deer to chronic wasting disease. Analysis of 300 transmissions of different forms of TSEs to nonhuman primates revealed that rhesus monkeys had the lowest rate of successful transmission. Analysis of the PRNP gene has been initiated to elucidate the role of genetic factors in susceptibility of rhesus monkeys to TSE.