CORE--STATISTICAL

统计核心负责协调科学 各项目和核心之间的活动以及预算规划， 数据库管理和统计服务。此外，还将促进 为特殊问题量身定制的新分析方法的发展 当许多不同的措施都是 在相对较小的人口中拍摄。我们对这个问题的解决方案 包括：(A)对分析水平的限制 假设适用，(B)将多个变量聚合成一个 单一稳健变量，(C)对假设的顺序的限制 被测试，和/或对单个变量的方式的约束 在单一复杂模型中使用，以及(D)明确和富有成效的分离 假设检验(验证性分析)和假设之间 生成(探索性分析)。我们还概述了整合的计划 对多中心内正在研究的人群进行分析， 包括构建可用于系统交叉的模型 人口比较。

The Statistics Core is responsible for the coordination of scientific activity among the various projects and cores, and for budgetary planning, data base management, and statistical services. In addition, will promote the development of new analytic procedures tailored to the special problems that danger of capitalizing on chance when many different measures are taken with relatively small populations. Our solutions to this problem include (a)constraints on the level of analysis to which a strong hypothesis applies, (b) methods for aggregating multiple variables into a single robust variable, (c) constraints on the order in which hypotheses are tested, and/or constraints on the way that individual variables are used within a single complex model, and (d) a clear and fruitful separation between hypothesis testing (confirmatory analysis) and hypothesis generation (exploratory analysis). We also outline plans for integrative analyses across the populations under study within the Multicenter, including the construction of models that can be used for systematic cross- population comparisons.