African critical care registry network for pandemic surveillance, clinical management and research.

非洲患者没有参与与COVID-19相关或其他疾病的不适患者的临床研究，从而剥夺了整个人群的权利，阻碍了大流行应对。潜在的原因与基础设施、数据可用性、专有技术和机会有关。具有大流行应对专业知识的集团和项目合作伙伴将通过三项活动来解决这一知识差距和潜在的业务（和机会）差距。在7个国家的35个重症监护病房，按照ISARIC协议，采用惠康支持的9个国家平行网络中使用的方法，为患有和不患有COVID-19的不适患者实施适应环境的登记。登记输出将包括患者特征、护理过程质量和结果。我们还将开展全国重症监护服务评估。确定利益相关者（临床医生和社区）的研究重点，以利用活动1的产出改善重症监护过程和结果，特别是对孕妇和手术患者。2 .我们将利用这些数据，为包括公众在内的所有人举办讲习班，确定利益攸关方在改进、大流行病应对和进一步研究方面的优先事项。在注册基础设施、我们的团队和项目合作伙伴的支持下，我们将招募网络站点参与所有类型的临床研究，这些研究将有利于人群的健康和福祉。该网络将通过指导、注册患者招募和研究监测等方式直接协助医生和护士参与研究。

Patients from Africa are not represented in clinical research for unwell patients, COVID-19 related or otherwise, thus disenfranchising entire populations and stymying pandemic response. The underlying reasons are related to infrastructure, data availability, knowhow and opportunity. Our group and project partners with pandemic response expertise will address both this knowledge gap and the underlying operational (and opportunity) gap by three activities.1.Implementing a setting-adapted registry for unwell patients with and without COVID-19, compliant with the ISARIC protocol in 35 critical care units in seven countries adopting methods used in a parallel Wellcome-supported nine country network. Registry output will include patient characteristics, quality of care processes and outcomes. We will also do a national critical care service evaluation.2.Identifying stakeholder (clinician and community) research priorities to improve critical care processes and outcomes leveraging activity 1 output, especially for pregnant women and surgical patients. We will determine stakeholder priorities for improvement, pandemic response and further research by using the data to facilitate workshops for all, including the public.3.We will recruit network sites to participate in all types of clinical research that will benefit population health and wellbeing, supported by the registry infrastructure, our group and project partners. The network will directly assist doctors and nurses participate in research through mentorship, registry enabled patient recruitment and study monitoring.