CASE CONTROL ETIOLOGIC STUDY OF SARCOIDOSIS

美国的10个临床中心正在为这项NIH申办的研究招募病例。 这些目标包括：1）检验关于结节病的环境、职业、生活方式和其他危险因素的假设，2）检查结节病的家族聚集性，3）检验关于结节病聚集性的遗传假设，4）描述结节病的自然史，特别是在似乎受到不成比例影响的非裔美国人等群体中，5）确定发展为更严重疾病的风险因素和6（实施用于存储生物样本的系统，所述生物样本包括血细胞，血浆，以及来自病例和对照受试者的血清和来自良好表征的一系列结节病病例的支气管肺泡灌洗液和细胞，严重的疾病。

Ten clinical centers in the United States are recruiting cases for this NIH sponsored study. The objectives include: 1) to test hypotheses concerning environmental, occupational, lifestyle, and other risk factors for sarcoidosis, 2) examine the familial aggregation of sarcoidosis, 3) To test genetic hypotheses concerning aggregation of sarcoidosis, 4) To describe the natural history of sarcoidosis, particularly among groups such as African-Americans who appear to be disproportionately affected, 5) To identify risk factors for progression to more sever disease and 6( To implement a system for storing biological specimens including blood cells, plasma, and serum from cases and control subjects and bronchoalveolar lavage fluid and cells from a well characterized series of cases of sarcoidosis which represent the spectrum from mild to severe disease.