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IMMUNOTHERAPY OF MALIGNACY BY IN VIVO GENE TRANSFER INTO TUMORS

IMMUNOTHERAPY OF MALIGNACY BY IN VIVO GENE TRANSFER INTO TUMORS
通过体内基因转移至肿瘤来免疫治疗恶性肿瘤
批准号：
6297121
负责人：
ALFRED E CHANG
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6297121
关键词：
DNA clinical research clinical trial phase I gene therapy histocompatibility antigens human subject human therapy evaluation liposomes major histocompatibility complex neoplasm /cancer immunotherapy transfection /expression vector

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中文摘要
翻译
在这项研究中，我们建议测试一种实验性疗法的安全性和有效性，该疗法旨在诱导目前无法治愈的肿瘤消退。这将通过将DNA/脂质体复合物直接递送到肿瘤中来完成，该复合物指导组织相容性抗原B7的合成。当这种蛋白在肿瘤表面表达时，会刺激恶性组织的免疫排斥反应。
英文摘要
In this study we propose to test the safety and efficacy of an experimental therapy designed to induce regression of tumors that are currently incurable. This will be accomplished by the delivery, directly into the tumor, of a DNA/liposome complex that directs the synthesis of histocompatibility antigen B7. This protein, when expressed on the surface of the tumor, stimulates immune rejection of the malignant tissue.
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会议论文
IMMUNOLOGICAL MONITORING
RESEARCH TRAINING IN TRANSLATIONAL TUMOR IMMUNOLOGY
IMMUNE RESPONSES INDUCED BY GENE TRANSFER
T CELL ACTIVATION FOR CANCER IMMUNOTHERAPY
海外基金