GENERAL CLINICAL RESEARCH CENTER

埃默里大学综合临床研究中心由来已久 杰出的临床研究历史。这样做的主要目标是 5年续期申请是为了提供设施和资源 因此，现有的和不断增加的未完成的新 基础科学和临床研究人员可以从事重要领域的研究 临床研究。研究的具体目标和主要领域 在涉及76名调查人员的44项明确协议中概述了所提出的建议。 这些包括：1)关于慢性肝病和并发症的研究 如代谢性骨病；肝功能研究和 肝病的血流动力学，包括肝脏的影响 多种血管移植对血流动力学的调节作用 药理药物；2)肾脏疾病的研究，包括 营养干预可能延缓进展为 终末期肾病；3)内分泌学研究，包括肥胖； 葡萄糖和乳酸代谢的改变；胰岛素抵抗和 糖尿病；胰岛素受体的基因调控；治疗试验 生长激素和生长抑素的营养调节。 生长抑素；4)血液学/肿瘤学研究，包括 研究血小板的产生和破坏；5)研究 心脏病学，比较球囊血管成形术和搭桥手术 冠心病的治疗；6)遗传性疾病的研究 线粒体功能，包括线粒体肌病，以及 研究核突变的分子方法，如Emery-Dreifuss 肌肉营养不良；以及7)新陈代谢先天缺陷的研究， 特别是枫糖浆产生的酶和分子机理 尿病、苯丙酮尿症、血色素沉着症和卟啉症。总的来说， 这些项目侧重于重要的内科、外科和儿科卫生。 新发现和治疗可能对其产生重大影响的疾病 冲击力。 为了实现这些目标，我们提供了一支优秀的现有和 新的调查人员，来自埃默里大学的丰富的患者材料 附属医院和诊所，一个严格管理的12张床位的诊所 拥有经验丰富的研究护士的研究设施，核心实验室 拥有新陈代谢平衡研究专业知识的营养/热量测量团队 和新陈代谢厨房，一种新开发和配备的分子生物学 实验室，一个高度组织的生物统计支持单位和CLINFO 计算机资源，以及一所致力于卓越的大学 在研究方面。

The General Clinical Research Center of Emory University has a long history of outstanding clinical research. The primary objective of this 5-Year renewal application is to provide the facilities and resources whereby both the existing and an increasing number of outstanding new basic science and clinical investigators can pursue important areas of clinical research. The specific aims and major areas of research proposed are outlined in 44 defined protocols involving 76 investigators. These include: 1) studies on chronic liver diseases and complications such as metabolic bone disease; studies of hepatic function and hemodynamics in liver disease, including the effects of liver transplantation and modulation of hemodynamics by a variety of pharmacologic agents; 2) studies of kidney disease, including the mechanisms by which nutritional intervention might retard progression to end-stage renal disease; 3) studies in endocrinology, including obesity; alterations in glucose and lactate metabolism; insulin resistance and diabetes; genetic regulation of insulin receptors; therapeutic trials with growth hormone; and nutritional regulation of somatomedin and somatomedin inhibitors; 4) studies in hematology/oncology, including investigation of platelet production and destruction; 5) studies in cardiology, comparing balloon angioplasty with bypass graft surgery for treatment of coronary artery disease; 6) studies of inherited disorders of mitochondrial function, including the mitochondrial myopathies, and molecular approaches to nuclear mutations such as the Emery-Dreifuss muscular dystrophy; and 7) studies of inborn errors of metabolism, especially the enzymatic and molecular mechanisms producing maple syrup urine disease, phenylketonuria, hemochromatosis and porphyria. Overall, these projects focus on important medical, surgical and pediatric health disorders for which new discoveries and treatments could have a major impact. To accomplish these aims, we offer an outstanding team of existing and new investigators, a wealth of patient material from the Emory University Affiliated Hospitals and Clinic, a tightly administered 12-bed clinical research facility with experienced research nurses, a core laboratory with expertise in metabolic balance studies, a nutrition/calorimetry team and metabolic kitchen, a newly developed and equipped molecular biology laboratory, a highly organized biostatistical support unit and CLINFO computer resource, and a University with a vital commitment to excellence in research.