HDHL MICA: Microbiota-Inflammation-Brain axis in heart failure ... (AMBROSIA)

老年人长期有限的饮食摄入量(营养不良)会极大地增加健康不良的风险，并增加虚弱。营养不良是被诊断为心力衰竭和心房颤动(导致心跳不齐的问题)的患者的常见问题。在这组患者中，改善饮食摄入量可以改善身体功能，还应该降低未来心脏问题的风险。这项欧盟合作(安布罗西亚项目)的目的是测试饮食咨询和提供一种新的强化食品产品是否可以使这一患者群体受益。这项合作研究了四个不同的国家(意大利、爱尔兰共和国、西班牙和英国)，汇集了工业界和学术界的专家。这项研究的第一个目标将是设计一种新的食品(安布罗西亚棒)，它特别富含蛋白质、纤维和其他因素的理想组合。将在120名心力衰竭和房颤患者中评估饮食咨询的影响，无论是单独的还是与安布罗西卡一起摄入的。将从患者那里收集血液样本、饮食数据、认知测试和身体成分测量，以跟踪这两种治疗的影响。对血液、尿液和粪便样本的额外分析还将分析代谢物和肠道微生物区系的更广泛变化，这将有助于理解这些因素与疾病管理的关系。使用尖端的机器学习方法也将有助于发现饮食摄入量、身体虚弱和健康状况的新“签名”。这些发现将对理解饮食摄入量对支持积极老龄化的影响有更广泛的好处

Long-term limited dietary intake (undernutrition) in older adults can greatly increase the risk of ill-health and increase frailty. Undernutrition is a common issue in patients diagnosed with heart failure and atrial fibrillation (an issue which causes an irregular heartbeat). Improving dietary intake in this patient group could improve physical functionality and should also reduce risk of future heart issues. The aim of this EU collaboration (the AMBROSIA project) is to test whether dietary counselling and provision of a novel fortified food product can benefit this patient group. This collaboration researchers across four different countries (Italy, Republic of Ireland, Spain and the UK) and bring together industrial and academic expertise.The first goal of this study will be to design the novel food product (the AMBROSIA bar), specifically enriched an ideal mix of protein, fibre and other factors. The impacts of dietary counselling, either alone or in tandem with AMBROSIA bar intake will be assessed in 120 heart failure and atrial fibrillation patients. Blood samples, dietary data, cognitive testing and measurements of body composition will be collected from patients to track the impact of these two treatments. Additional analysis of blood, urine and stool samples will also analyse wider changes in metabolites and gut microbiota that will support understanding of the relationship of these factors with disease management. Use of cutting-edge machine-learning approaches will also help to uncover new "signatures" of dietary intake, frailty and health status. Such findings would have wider benefit on the understanding of the impact of dietary intake on supporting positive ageing