GLUCOCORTICOID FEEDBACK EFFECTS ON ACTH SECRETION IN DEPRESSION

重度抑郁症患者和健康对照者接受四次标准方案。每次他们接受的治疗分别是：皮质醇（氢化可的松）7.5毫克、皮质醇20毫克、皮质醇50毫克或安慰剂。试验物质给药是双盲的、无序的；在四项协议中，受试者接受每种测试物质。在标准方案中，在给药前30分钟和给药后4小时，通过静脉导管抽取血液以测定皮质醇和ACTH。

Patients with major depression and healthy control subjects undergo a standard protocol on four occasions. Each time they receive one of: cortisol (hydrocortisone) 7.5 mg, cortisol 20 mg, cortisol 50 mg or placebo. Test substance administration is double blind and in random order; over the four protocols subjects receive each test substance. In the standard protocol blood is drawn through an IV catheter for cortisol and ACTH determinations at regular intervals for 30 min before and 4 h after administration of the test substance.