EFFECT OF INSULIN RESISTANCE ON THE LIPOPROTEIN RESPONSE TO EGG FEEDING

为了确定胰岛素抵抗或肥胖是否与食用鸡蛋后的血脂反应有关，201名受试者将被分为三个相等的组，瘦型胰岛素敏感组、瘦型胰岛素抵抗组和肥胖型胰岛素抵抗组，使用胰岛素敏感性指数<或> 7.0，由频繁采样的静脉葡萄糖耐量试验确定，BMI >或< 27.5 kg/m2。受试者将从机构人员和公共广告中招募，教授NCEP第一步（中等低脂肪）饮食，并在三个随机的每月方案中以每天0、2或4个鸡蛋的水平饲喂巴氏消毒全蛋和/或鸡蛋替代品的双盲交叉设计，间隔一个月的洗脱期。鸡蛋喂养的影响将通过ldl -胆固醇的变化，以及hdl -胆固醇、载脂蛋白B和密度梯度垂直分析脂蛋白模式的变化来评估。

To determine if insulin resistance or obesity is associated with plasma lipid response to egg consumption, 201 subjects will be divided into three equal groups, lean insulin sensitive, lean insulin resistant, and obese insulin resistant, using an insulin sensitivity index < or > 7.0 determined by a frequently sampled IV glucose tolerance test and BMI > or < 27.5 kg/m2. Subjects will be recruited from institutional personnel and public advertising, taught the NCEP Step I (moderately low fat) diet and fed in a double-blind cross-over design pasteurized whole egg and/or egg substitute in three randomized monthly protocols at levels of 0, 2 or 4 eggs daily, separated by one month washout periods. The effect of egg feeding will be assessed by changes in LDL-cholesterol, and also by changes in HDL-cholesterol, apoprotein B and density gradient vertical analytical profiles of the lipoprotein pattern.