CATCH IR--CANDESARTAN IN AFRICAN AMERICANS W/ HYPERTENSION & INSULIN RESISTANCE

与所有其他种族相比，非裔美国人患高血压及其并发症的风险最高。这强调了在这一高危人群中对这种疾病进行进一步调查以更有效地设计治疗方法的必要性。众所周知，血管紧张素在高血压演变过程中血管增厚的发展过程中起着重要作用。此外，有证据表明，阻断这种荷尔蒙效应可能会消融这些对血管的影响。胰岛素抵抗是一种对循环胰岛素的反应性降低的状况，与高血压有关。胰岛素抵抗的主要部位发生在骨骼肌。骨骼肌血液供应的变化可能会导致胰岛素敏感性的变化。这项研究建议通过两种可靠的方法评估血管紧张素受体阻滞剂坎地沙坦西替利对非裔美国人胰岛素敏感性的影响。

African Americans have the highest risk of developing hypertension and its complications compared to all other ethnic groups. This emphasizes the need for further investigation into this disease in this high risk population to design therapies more effectively. It is clearly known that the hormone angiotensin is important in the development of thickened blood vessels in the evolution of hypertension. Additionally, there is evidence to show that blocking this hormonal effect may ablate these effects on blood vessels. Insulin resistance, a condition of decreased responsiveness to circulating insulin, is associated with hypertension. The primary site of insulin resistance occurs in the skeletal muscle. A change in blood supply to the skeletal muscle may result in changes in insulin sensitivity. This study proposes to evaluate the effect of an angiotensin receptor blocker (Candesartan cilextil) on insulin sensitivity in African Americans by two reliable methods.