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WHOLE LIVER RADIATION DOSE ESCALATION TRIAL UTILIZING ETHYOL AMIFOSTINE

WHOLE LIVER RADIATION DOSE ESCALATION TRIAL UTILIZING ETHYOL AMIFOSTINE
使用乙基氨磷汀的全肝辐射剂量递增试验
批准号：
6263665
负责人：
CORNELIUS J MCGINN
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6263665
关键词：
clinical research clinical trial phase I combination cancer therapy human subject liver neoplasms neoplasm /cancer chemotherapy neoplasm /cancer radiation therapy radiation therapy dosage thiophosphate whole body irradiation dosage

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中文摘要
翻译
虽然放射治疗已被证明在治疗肝内癌患者方面有效，但其在治疗整个肝脏方面的有效性受到可耐受的低总剂量的限制。 在这项I期研究中，将使用Ethyol（氨磷汀），试图向整个肝脏输送更高的总剂量。 该药物是一种有机硫代磷酸盐，已开发用于选择性保护正常组织免受化疗和放疗的毒性。 放射治疗将与肝动脉（HA）尿苷（FUdR）同时进行，就像我们以前的全肝放射治疗试验一样。
英文摘要
Although radiation has proven efficacy in the treatment of patients with intrahepatic cancers, its usefulness in the treatment of the whole liver is limited by the low total dose that can be tolerated. In this phase 1 study, Ethyol (amifostine) will be used in attempt to allow delivery of a higher total dose to the whole liver. This agent is an organic thiophosphate that has been developed to selectively protect normal tissues against the toxicities of chemotherapy and radiation. Radiation will be delivered concurrent with hepatic arterial (HA) floxuridine (FUdR), as it has been in our previous whole liver radiotherapy trials.
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会议论文
WHOLE LIVER RADIATION DOSE ESCALATION TRIAL UTILIZING ETHYOL AMIFOSTINE
WHOLE LIVER RADIATION DOSE ESCALATION FOR INTRAHEPATIC CANCERS
LOW DOSE LIVER IRRADIATION WITH HEPATIC ARTERIAL CHEMOTHERAPY FOR CANCER
RADIATION DOSE ESCALATION FOR FOCAL LIVER CANCER
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