课题基金 / 基金详情

WHOLE LIVER RADIATION DOSE ESCALATION FOR INTRAHEPATIC CANCERS

WHOLE LIVER RADIATION DOSE ESCALATION FOR INTRAHEPATIC CANCERS
肝内癌的全肝脏辐射剂量递增
批准号：
6263650
负责人：
CORNELIUS J MCGINN
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6263650
关键词：
clinical research clinical trials human subject human therapy evaluation liver neoplasms neoplasm /cancer radiation therapy radiation therapy dosage radiobiology whole body irradiation dosage

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中文摘要
翻译
虽然放射治疗已被证明在治疗肝内癌方面有效，但其有效性受到可耐受的低剂量的限制。剂量限制性毒性被称为放射性肝病（RILD）。 这种病变的病理与其他原因引起的肝静脉闭塞病（VOD）相同。 本试验将评估全肝放射剂量递增的可行性，如果发生RILD，则使用肝素预防RILD和阿替普酶（重组组织型纤溶酶原激活剂，rt-PA）积极管理RILD。 该策略已成功用于治疗骨髓移植后的肝VOD。
英文摘要
Although radiation has proven efficacy in the treatment of intrahepatic cancers, its usefulness is limited by the low dose that can be tolerated. The dose limiting toxicity is referred to as Radiation Induced Liver Disease (RILD). The pathology of this lesion is identical to that of hepatic veno-occlusive disease (VOD) produced by other causes. This trial will assess the feasibility of whole liver radiation dose escalation utilizing heparin prophylaxis for RILD and alteplase (recombinant tissue-type plasminogen activator, rt-PA) to actively manage RILD should it occur. This strategy has been used successfully to treat hepatic VOD following bone marrow transplant.
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会议论文
WHOLE LIVER RADIATION DOSE ESCALATION TRIAL UTILIZING ETHYOL AMIFOSTINE
WHOLE LIVER RADIATION DOSE ESCALATION FOR INTRAHEPATIC CANCERS
LOW DOSE LIVER IRRADIATION WITH HEPATIC ARTERIAL CHEMOTHERAPY FOR CANCER
RADIATION DOSE ESCALATION FOR FOCAL LIVER CANCER
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