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WHOLE LIVER RADIATION DOSE ESCALATION TRIAL UTILIZING ETHYOL AMIFOSTINE

WHOLE LIVER RADIATION DOSE ESCALATION TRIAL UTILIZING ETHYOL AMIFOSTINE
使用乙基氨磷汀的全肝辐射剂量递增试验
批准号：
6297022
负责人：
CORNELIUS J MCGINN
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6297022
关键词：
clinical research clinical trial phase I combination cancer therapy human subject liver neoplasms neoplasm /cancer chemotherapy neoplasm /cancer radiation therapy radiation therapy dosage thiophosphate whole body irradiation dosage

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中文摘要
翻译
尽管放射治疗在治疗开始于肝脏或扩散到肝脏的癌症患者方面已被证明有效，但其在治疗整个肝脏方面的有效性受到可安全耐受的低总剂量的限制。在这项第一阶段的研究中，乙醇(氨磷汀)将被用来尝试将更高的总剂量输送到整个肝脏。这种药物是为了选择性地保护正常组织免受化疗和辐射的毒性而开发的。
英文摘要
Although radiation has proven efficacy in the treatment of patients with cancers that started in or spread to the liver, its usefulness in the treatment of the whole liver is limited by the low total dose that can be safely tolerated. In this phase 1 study, Ethyol (amifostine) will be used in attempt to allow delivery of a higher total dose to the whole liver. This agent has been developed to selectively protect normal tissues against the toxicities of chemotherapy and radiation.
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会议论文
WHOLE LIVER RADIATION DOSE ESCALATION TRIAL UTILIZING ETHYOL AMIFOSTINE
WHOLE LIVER RADIATION DOSE ESCALATION FOR INTRAHEPATIC CANCERS
LOW DOSE LIVER IRRADIATION WITH HEPATIC ARTERIAL CHEMOTHERAPY FOR CANCER
RADIATION DOSE ESCALATION FOR FOCAL LIVER CANCER
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