SERUM AND URINE GONADOTROPINS IN SEX STEROIDS IN NORMALLY CYCLING WOMEN

作为一项为全国妇女大型多中心研究（SWAN）做准备的初步可行性研究，本方案将记录促性腺激素促卵泡激素（FSH）和促黄体生成素（LH）以及性腺类固醇雌二醇和孕酮的血清水平与FSH、LH以及类固醇代谢产物孕甾酮葡糖苷酸和雌酮葡糖苷酸的尿液水平之间的相关性。 本可行性研究将在7个临床研究中心招募共计35名女性。预计在准备大型母方案中计划的尿液研究时，将注意到尿液和血清水平之间的良好相关性。

As a pilot feasibility study in preparation for the large multi-center Study of Women Across the National (SWAN), this protocol will document the correlation between serum levels of the gonadotropins follicle stimulating hormone (FSH) and lutinizing hormone (LH) and the gonadal steroids estradiol and progesterone with urinary levels of FSH, LH and the steroid metabolites pergnanediol glucuronide and estrone glucuronide. A total of 35 women will be recruited at 7 clinical sites for this feasibility study. It is anticipated that good correlation between urinary and serum levels will be noted in preparation for the planned urinary studies in the larger parent protocol.