SYSTEMIC PROSTAGLANDIN E1 ON UREA SYNTHESIS/WHOLE BODY NITRGN METAB IN CIRRHOSIS

本研究的目的是评价前列腺素E_1在肝硬变患者和配对的健康对照组中的代谢效应。被检验的假说是：1)前列腺素E_1显著影响肝硬变患者的肝脏和全身氨基氮经济；2)前列腺素E_1导致尿素合成减少；3)前列腺素E_1可能通过减少氨基酸外流或增加氨基酸摄取和非氧化代谢作用于外周组织。到目前为止，已经招收了4名受试者。还没有进行任何数据分析。

The aim of this study is to evaluate the metabolic effects of prostaglandin E1 administration in patients with liver cirrhosis and paired healthy controls. The hypotheses being tested are: 1) Prostglandin E1 significantly influences hepatic and whole body amino nitrogen economy in patients with liver cirrhosis; 2) Prostaglandin E1 produces a decrease in urea synthesis, and 3) Prostaglandin E1 might act on the peripheral tissues, through a decreased amino acid efflux, or increased amino-acid uptake and non-oxidative metabolism. To date 4 subjects have been enrolled. No data analysis has been done.