FACTORS AFFECTING FETAL GROWTH

本研究的长期目标是评估瘦素、肿瘤坏死因子α、胰岛素和c肽与新生儿体成分，特别是新生儿脂肪量之间的关系。第二个目的是评估这些因素作为可能的调节和机制有关胎儿子宫内生长。我们计划通过收集GDM和NGT母亲的婴儿的脐动脉和静脉脐带血，胰岛素和c肽来验证这些假设。最后，在出生后48小时，从新生儿中获得瘦素和肿瘤坏死因子α，以确定胎儿瘦素和肿瘤坏死因子α的产生是否在出生后减少。

The long term goal of this study is to evaluate the relationship among leptin, tumor necrosis factor alpha, insulin, and c-peptide with neonatal body composition, specifically neonatal fat mass. The secondary aim is to evaluate these factors as possible regulators and mechanisms relating to fetal intra-uterine growth. We plan to test the hypotheses by collecting umbilical artery and vein cord blood from both infants of mothers with GDM and NGT, insulin and c-peptide. Finally, leptin and tumor necrosis alpha will be obtained from the neonates at 48 hours of life to determine if fetal leptin and tumor necrosis factor alpha production decreases following birth.