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HBY 097 EFFECTS ON PLASMA CONCENTRATIONS OF INDINAVIR AND ZIDOVUDINE IN HIV

HBY 097 EFFECTS ON PLASMA CONCENTRATIONS OF INDINAVIR AND ZIDOVUDINE IN HIV
HBY 097 对 HIV 患者茚地那韦和齐多夫定血浆浓度的影响
批准号：
6115462
负责人：
FRANCESCA T. AWEEKA
金额：
$3.1万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6115462
关键词：
AIDS AIDS therapy HIV infections antiAIDS agent antiviral agents clinical research cytochrome P450 drug interactions drug metabolism drug screening /evaluation enzyme activity human subject human therapy evaluation indinavir outcomes research pharmacokinetics reverse transcriptase inhibitors

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中文摘要
翻译
本研究旨在评估一种潜在的药代动力学药物
英文摘要
This study is designed to evaluate a potential pharmacokinetic drug interaction between indinavir, zidovudine, and a new non-nucleoside reverse transcriptase inhibitor HBY-097. Indinavir and HBY-097 are both metabolized by the same cytochrome P450 pathway, so there is a chance that the combination will result in altered drug elimination.
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