PET EVALUATION OF BUCCAL ABSORPTION OF C 11 LABELED TAA

本研究的目的是定量评估曲安奈德(TAA)在肺部的生物分布，这是由于口腔吸收随时间的变化。这项研究的目的是对口腔粘膜中药物的萃取率和肺部对标记药物的摄取进行定量估计。如果在肺部观察到显著的摄取，将估计吞咽药物和代谢物的口腔吸收和全身吸收对肺摄取的单独贡献。先前已经证明，使用口服木炭浆可以防止吞咽药物的任何全身吸收。因此，使用该浆料将允许将吞咽药物的吸收估计为两种口腔吸收测量之间的差异，在每个个体中，使用木炭和不使用木炭。研究数据正在分析中。

The objective of this study is to quantitatively evaluate the biodistribution of triamcinolone acetonide (TAA) in the lungs due to buccal absorption as a function of time. The study aims to produce quantitative estimations of the rate of drug extraction from the oral mucosa and of the uptake of labeled drug in the lungs. If significant uptake is observed in the lungs, the separate contributions to the lung uptake which may be provided by buccal absorption and by systemic absorption of swallowed drug and metabolites will be estimated. The use of oral charcoal slurry has previously been shown to prevent any systemic absorption of swallowed drug. Use of the slurry will therefore allow absorption of swallowed drug to be estimated as the difference between two measurements of buccal absorption, with and without charcoal, in each indivudal. The study data is being analyzed.