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ESTIMATION OF ORAL CYSTEAMINE BITARTRATE AT STEADY STATE IN CYSTINOSIS

ESTIMATION OF ORAL CYSTEAMINE BITARTRATE AT STEADY STATE IN CYSTINOSIS
胱氨酸中毒稳态时口服半胱胺酒石酸氢盐的估计
批准号：
6265204
负责人：
JERRY A SCHNEIDER
金额：
$1.15万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6265204
关键词：
blood chemistry clearance rate clinical research cysteamine cystinosis dosage drug screening /evaluation human subject human therapy evaluation leukocytes longitudinal human study metabolism disorder chemotherapy oral administration

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中文摘要
翻译
在服药后5小时、1小时、1.5小时、2小时、3小时和6小时抽血测定白血球半胱氨酸和血浆半胱胺水平，这些患者已达到最大剂量，并已维持该剂量至少6个月。评估患者6小时给药间隔内Cystagon的清除情况。
英文摘要
Blood draws to determine white blood cell cystine and plasma cysteamine levels at hours .5, 1, 1.5, 2,3 and 6 post dosing in patients who have reached their maximum dose of cystagon and who have maintained this dose for at least 6 months. Evaluate the clearance of cystagon over the patient's 6 hour dose interval.
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