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DEPRESSION EFFECT OF REM SLEEP SUPPRESSION BY MAOI PHENELZINE

DEPRESSION EFFECT OF REM SLEEP SUPPRESSION BY MAOI PHENELZINE
MAOI 苯乙肼抑制快速眼动睡眠的抑郁效应
批准号：
6265188
负责人：
JOHN C GILLIN
金额：
$1.15万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6265188
关键词：
REM sleep adrenocorticotropic hormone antidepressants body temperature circadian rhythms clinical research cortisol dreams drug administration rate /duration drug screening /evaluation electroencephalography emotions human subject human therapy evaluation major depression melatonin memory mental disorder chemotherapy neuroendocrine system phenelzine polygraphy

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中文摘要
翻译
为了扩大对睡眠在健康和疾病中的调节和功能的认识，本研究将调查抗抑郁药苯乙肼(Nardil)对重度抑郁症患者至少5周的效果。将评估对情绪、记忆力、多导睡眠测量、睡眠脑电、昼夜节律位置(通过神经内分泌测量褪黑激素、促肾上腺皮质激素、皮质醇和体温评估)和梦境回忆的影响。
英文摘要
To extend knowledge on the regulation and the functions of sleep in health and disease, this study will investigate the effect of the antidepressant phenelzine (Nardil) for at least 5 weeks in patients with major depression. Effect on mood, memory, polygraphic sleep measures, the sleep EEG, circadian phase position (assessed by neuroendocrine measures melatonin, ACTH, cortisol and body temperature) and dream recall will be assessed.
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