AN ADOESCENT WITH CENTRAL HYPOVENTILATION SYNDROME

血清素能机制与中枢性通气不足综合征有关。 5-羟色胺能神经元位于解剖学上接近心肺控制区域的区域。 我们推测，中枢性肺通气不足青少年的氧合改善是继发于氟西汀的增加。 据信，在睡眠期间给予替吉奥对上呼吸道通畅性有不利影响。 我们假设这些影响将通过贴片持续输送睾酮来消除。 在其治疗方案中添加氟西汀避免了切肠术的需要，停用氟西汀导致其氧合恶化。 通过贴剂给药替吉奥不会对上气道通畅性产生不良影响。 研究完成。

Serotonergic mechanisms have been implicated in central hypoventilation syndrome. Serotonergic neurons are in an area anatomically close to areas of cardiorespiratory control. We hypothesize that improvement in oxygenation in an adolescent with central hypoventilation was secondary to the addition of fluoxetine. Testosterone administration is believed to have an adverse influence on upper airway patency during sleep. We hypothesize these effects will be obviated by continous delivery of testosterone via a patch. Addition of fluoxetine to his regimen averted the need for xracheostomy, withdrawal of fluoxetine resulted in deterioration of his oxygenation. Testosterone administration by patch did not adversely affect upper airway patency. Study completed.