课题基金 / 基金详情

PIVOTAL EFFICACY STUDY OF INHIBITION OF GASTRIC ACID SECRETION BY PANTOPRAZOLE

PIVOTAL EFFICACY STUDY OF INHIBITION OF GASTRIC ACID SECRETION BY PANTOPRAZOLE
泮托拉唑抑制胃酸分泌的关键功效研究
批准号：
6118462
负责人：
JOSEPH R PISEGNA
金额：
$0.19万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6118462
关键词：
Zollinger Ellison syndrome antiulcer drug benzimidazoles clinical research clinical trials drug screening /evaluation endocrine neoplasm gastric acid gastric juice inhibitor gastrointestinal disorder chemotherapy human subject human therapy evaluation intravenous administration secretion stomach surgery

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相关文献

中文摘要
翻译
目的是确定静脉（IV）给药泮托拉唑的方案，使未行部分胃切除术的伴有或不伴有多发性内分泌肿瘤I型（MEN-I）综合征的Zollinger-Ellison综合征（ZES）患者的胃酸分泌量降低并维持在低于10mEq/ hr，而伴有或不伴有man -I且行胃大部切除术的伴有或不伴有man -I的ZES患者的胃酸分泌量低于5meq /hr，且安全性较低。
英文摘要
The objective is to identify the regimens of intravenously(IV) administered pantoprazole that would decrease and maintain acid secretion at less than 10mEq/ hr in patients with Zollinger-Ellison syndrome (ZES) with or without multiple endocrine neoplasia-type I (MEN-I) syndrome who have not under- gone partial gastrectomy and at less than 5 mEq/hr in those patients with ZES with or without MEN-I who have undergone parital gastrectomy and to minor safety.
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