THERAPEUTIC TARGETS FOR INOSINE MONOPHOSPHATE DEHYDROGENASE (II)

人肌氨酸单磷酸脱氢酶2(IMPDH(II)) 催化鸟嘌呤从头合成的关键步骤 核苷酸。它是一个同源异构体，每个亚基大约58 KD。(Ii)IMPDH似乎是可诱发的。它的表达式是 增殖过程中升高，分化过程中下降。 抑制IMPDH(II)减少细胞内鸟嘌呤核苷酸池 并抑制细胞增殖。IMPDH的抑制作用(II) 使其成为一种可行的治疗靶点 免疫抑制、牛皮癣、抗癌和抗病毒化疗。

Human Inosine Monophosphate Dehydrogenase type 2 (IMPDH(II)) catalyzes the committed step of de novo biosynthesis of guanine nucleotides. It is a homotetratmer with each subunit approximately 58 kD. Type (II) IMPDH appears to be inducible. Its expression is elevated during proliferation and decreases during differentiation. Inhibition of IMPDH(II) reduces intracellular guanine nucleotide pools and inhibits cellular proliferation. The inhibition of IMPDH(II) makes it a viable candidate for therapeutic targets in immunosuppression, psoriasis, anticancer and antiviral chemotherapy.