VERY HIGH RESOLUTION XRAY DATA COLLECTION ON DIMERIZATION DOMAIN OF HNF 1A

在HNF-p1上收集非常高分辨率的数据将使我们能够 用直接法求解晶体结构。这将是 详细了解HNF-1的二聚化基序，它具有 已经被提出以扭结的螺旋对或四螺旋束状存在。 游离DCoH和DCoH/HNF-p1复合体的结构比较 允许我们定义中介识别的交互，并 描述任何可能有助于刺激基因的构象变化 表情。

Collection of very high resolution data on HNF-p1 would enable us to solve the crystal structure using direct methods. This will provide a detailed look at the HNF-1 dimerization motif, which has been proposed to exist as a kinked helix pair or a four-helix bundle. Comparison with structures of free DCoH and DCoH/HNF-p1 complex would allow us to define interactions that mediate recognition and to characterize any conformational changes that may help stimulate gene expression.