PERFUSION MODELING OF MAGNETIC RESONANCE IMAGING OF HEART USING MMID4

我们研究的目标是非侵入性量化 心肌血流量(毫升/分钟每克组织) 磁共振(MR)造影剂首次通过时的磁共振成像。 为了准确估计血液的多路径，轴向分布 毛细血管组织交换模型(MMID4) 利用仿真资源对第一道工序进行分析 残余曲线测定心肌血流量。的概念 心肌血流量的磁共振定量正在进行中 在动物模型中得到验证，在动物模型中，使用放射性同位素测量流量 以标记的微球作为金标准参照物。两者都有 使用细胞外和血管内造影剂来确定， 不仅是血流量，而且还有血容量(包括血管内 造影剂)、毛细血管通透性(与细胞外 造影剂)，以及血流和毛细血管之间的关系 渗透率表面积积(2)。来自这些的洞察力 血液的非侵入性量化研究正在进行中 在病人中流动。

The goal of our research is the non-invasive quantification of myocardial blood flow (in ml/min per g of tissue) with magnetic resonance (MR) imaging during the first pass of an MR contrast agent. For accurate estimation of blood a multi-pathway, axially distributed model of capillary tissue exchange (MMID4) developed at the National Simulation Resource is applied to the analysis of the first pass residue curves to determine myocardial blood flow. The concepts for the quantification with MR of myocardial blood flow are being validated in animal models, where flow measurements with radio-isotope labeled microspheres are used as gold standard reference. Both extracellular and intravascular contrast agents are used to determine, not only blood flow, but also blood volume (with intravascular contrast agents), the capillary permeability (with extracellular contrast agents), and the relation between flow and the capillary permeability surface area product (2). The insights from these studies are being applied for the non-invasive quantification of blood flow in patients.