PROTEIN STRUCTURE DATABASE (PSDB)

这项计算工作涉及三项矫形外科研究 问题：模拟种植体周围的骨骼适应；计算 外源磁场在骨骼中产生的电场；以及 对机械加载的骨骼中的液体流动进行量化。模拟骨骼 适应是通过施加生理负荷和 犬股骨远端有限元模型的约束条件 使用骨重塑有限元程序模拟骨组织的变化 种植体周围骨的孔隙度和结构 试验性地插入股骨。重塑有限元 代码已在C90上成功使用，其他运行情况如下 需要进一步探讨不同加载条件的影响 关于由此产生的骨骼适应。电场问题是一部分 一个旨在将骨骼适应与电学联系起来的项目 场强，以找出所施加的电场和 火鸡模型中的生物反应。CODES利用 有限元方法和有限差分法将 探索一种最佳的感生电量量化方法 暴露在时变磁场中的火鸡翼上的磁场 菲尔德。对于流体在骨骼中的流动问题， 骨液和骨基质将用有限的 元素模型也基于火鸡模型。首先是有限元 模拟实验加载的骨的机械加载模型 将运行条件以计算 骨器官水平。然后将使用这些位移和应变 作为骨组织模型的边界条件，该模型包括 骨水流经的骨骼通道。一种有限元程序 将对引起流固耦合的因素进行研究。

This computational work addresses three orthopaedic research problems: simulating bone adaptation around an implant; calculating electric fields induced in bone by exogenous magnetic fields; and quantifying fluid flow in a mechanically loaded bone. Simulating bone adaptation is accomplished by applying physiological loads and constraints to a finite element model of the canine distal femur and using a bone remodeling finite element program to model the changes in porosity and architecture of the bone surrounding an implant experimentally inserted in the femur. The remodeling finite element code has successfully been used on the C90, and additional runs are needed to further explore the effects of different loading conditions on the resulting bone adaptation. The electric field problem is part of a project that is aimed at relating bone adaptation to electric field intensity to find a relationship between the applied fields and the biological response in a turkey model. Co des utilizing the finite element method and the finite difference method will be explored to find an optimal way to quantify the induced electric fields in a turkey wing that is exposed to a time-varying magnetic field. For the problem of fluid flow in bone, the interaction between the bone fluid and the bone matrix will be investigated using a finite element model also based upon a turkey model. First a finite element model of a bone mechanically loaded to mimic experimental loading conditions will be run to calculate displacements and strains on the bone-organ level. These displacements and strains will then be used as boundary conditions for a bone-tissue model that includes the small bone channels through which bone fluid flows. A finite element code that induces fluid-structure interaction will be investigated.