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CORE RESEARCH GRANT

CORE RESEARCH GRANT
核心研究补助金
批准号：
6282530
负责人：
DAVID W DEERFIELD
金额：
$1.19万
依托单位：
MELLON PITTS CORPORATION (MPC CORP)
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-08-01 至 1999-07-31
来源：
https://reporter.nih.gov/project-details/6282530
关键词：
biological products biomedical resource computers

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英文摘要
Cocaine's reinforcing effects are believed to be related to its ability to inhibit dopamine uptake. From behavioral studies, it appears that the D1, D2, D3, (and perhaps D4) receptor subtypes are involved in the reinforcing effects of cocaine. Selective antagonists for these receptor subtypes might be useful in the treatment of cocaine vs. D1 and D2, may be especially useful. Computational studies are currently underway to aid in the design of selective D3 (and D4) antagonist compounds. We require structural data for as man high-activity D2 and D3 compounds as possible to aid in our molecular modeling studies. This requested starting grant will be used to search x-ray crystallographic databases for that information.
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COMPUTATIONAL NEUROSCIENCE OVER THE ACCESS GRID NODES
  • 批准号：
    7601352
  • 项目类别：
  • 资助金额：
    $0.03万
  • 财政年份：
    2007
  • 负责人：
    DAVID W DEERFIELD
  • 依托单位：
    CARNEGIE-MELLON UNIVERSITY
COMPUTATIONAL NEUROSCIENCE OVER THE ACCESS GRID NODES
COLLABORATION GRANT WITH JONATHAN MINDEN/CMU AND JOSE-MARIE GRIFFITH/U OF NATI
Collaboration grant with Roger Fager
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