DEVELOPMENT OF CCD-BASED X-RAY DETECTOR SYSTEMS FOR STRUCT BIOL & MED IMAGING

我们是Brandeis的I-0成员小组，专注于开发和 描述最先进的X射线探测器在以下领域的应用 结构生物学和医学成像。这涉及到设计和 制造用于数据收集的硬件、电子设备和软件 和数据处理。设计标准包括：(1)大面积，(2) 读出速度快，(3)动态范围大，(4)空间分辨率高。 一个四模块探测器正在建造中，将用于NSLS 在光束线X25和X12-C处。 目标：该系统将在第一次赠款期间安装 年。该探测器将被表征，并将进行改进 寻求探测器的工程设计、读出逻辑和 电子产品，并与软件开发项目合作 (9.C.1.1)，与光束线和数据收集软件集成。 在4模块探测器项目完成后，我们预计将继续 在我们认为提供的两个领域中开发基于CCD的探测器 令人兴奋的可能性：(1)具有相当快的探测器 用于时间分辨和劳埃衍射研究的读数，以及(2) 基于大面积ccd的探测器。

We are a I 0-member group at Brandeis focused on developing and describing state-of-the-art x-ray detectors for applications in structural biology and medical imaging. This involves the design and fabrication of hardware, electronics, and software for data-collection and data-processing. Design criteria include: (1) a large area, (2) fast readout, (3) large dynamic range and (4) high spatial resolution. A four-module detector is under construction for the NSLS, to be used at beamlines X25 and X12-C. Objectives: This system will be installed during the first grant year. This detector will be characterized and improvements will be sought to the engineering of the detector, the readout logic and electronics, and, in cooperation with the software development project (9.c. 1. 1), integration with beamline and data-collection software. After the 4-module detector project is finished, we expect to continue development of CCD-based detectors in two areas that we believe offer exciting possibilities: (1) detectors with considerably faster readout for time-resolved and Laue-diffraction investigations, and (2) detectors based on large-area CCDs.