BASIC MECHANISMS OF VIRAL AND CHEMICAL CARCINOGENESIS

描述（申请人的描述）：本提案的目的是为18名博士后研究员在基础研究的定义领域进行跨学科培训的有组织计划提供持续支持，这些研究可能导致对癌症基本机制的深入了解。在42名导师的实验室进行的基础研究从Lineberger综合癌症中心的核心教师中选出，在分子致癌，病毒学，细胞生物学，免疫学，分子治疗学的既定计划中;新计划包括乳腺癌和放射生物学;和癌症遗传学的发展计划。来自14个部门，方案和课程的教师参加培训计划。所有42名导师都有独立的同行评审研究支持;自上次更新以来，年度支持总额（直接费用）从1 290万美元增加到2 030万美元。非常重视跨学科培训，这是由Lineberger综合癌症中心的理念和组织推动的，并由该中心用于培训的许多共享核心设施提供便利。对设施的支持来自该中心的核心支持赠款，该赠款已被更新并增加了20-24年的高度优先权，以及分子生物学和生物技术计划。每个研究员的培训计划在进入该计划时由导师，主任，助理主任，培训委员会和研究员个性化。根据受训者的需要强调具体特点，并监测每个受训者的进展情况。 由于转化研究的重要性，一部分学员将是对基础研究感兴趣的医生。为招收少数民族参加这一培训方案作出了特别努力。培训计划包括每周一次的系列研讨会，由研究员每月一次的内部研讨会系列，年度癌症中心研讨会，年度博士后教师研究日，由研究员选择的年度顾问，特别讲座，工作计划组和博士后研究员委员会。 该计划由主任和助理主任根据培训委员会和中心计划规划委员会的建议进行管理，并通过中心的培训和教育办公室进行协调和实施。 目前的要求是基于教师资金的显着增长和中心设施的扩大，高素质的申请人的大量增加，在过去5年中培训计划的进一步成熟，并上升到国家卓越的Lineberger综合癌症中心。

DESCRIPTION (Applicant's Description): The purpose of this proposal is to provide continuing support for an organized program of interdisciplinary training for 18 postdoctoral fellows in defined areas of basic research that are likely to lead to insights into the fundamental mechanisms of cancer. The basic research conducted in the laboratories of 42 preceptors selected from the core faculty of the UNC Lineberger Comprehensive Cancer Center are in the established programs in Molecular Carcinogenesis, Virology, Cell Biology, Immunology, Molecular Therapeutics; new programs including Breast Cancer and Radiobiology; and a developing program in Cancer Genetics. Faculty from 14 departments, programs and curricula participate in the training program. All 42 preceptors have independent peer-reviewed research support; total yearly support (direct costs) has increased from 12.9 to 20.3 million dollars since the last renewal. There is a strong emphasis on interdisciplinary training, promoted by the philosophy and organization of the UNC Lineberger Comprehen-sive Cancer Center and facilitated by the Center's many shared core facilities used for training. Support for the facilities comes from the Center's core support grant, which has been renewed and increased for years 20-24 with high priority, and from the Program in Molecular Biology & Biotechnology. The plan for training of each fellow is individualized upon entry to the program by the Preceptor, Director, Assistant Director, Training Committee, and fellow. Specific features are emphasized according to the needs of the trainees, and the progress of each trainee is monitored. Because of the importance of translational research, a subset of the trainees will be physicians interested in basic research. Special efforts are made to recruit minorities to this training program. The training program includes a weekly seminar series, a monthly in-house seminar series given by the fellows, the annual Cancer Center symposium, the annual Postdoctoral-Faculty Research Day, an annual consultant selected by the fellows, special lectures, working program groups, and a postdoctoral fellow committee. The program, administered by the Director & Assistant Director with the advice of the Training Committee & the Center's Program Planning Committee, is coordinated and implemented through the Center's Training and Education office. The present request is based on the significant growth in faculty funding and expansion of facilities of the Center, a large increase in highly qualified applicants, the further maturation of the training program during the past 5 years and rise to national excellence of the UNC Lineberger Comprehensive Cancer Center.