BRAIN ANATOMIC MRI IN CHILDHOOD BIPOLAR DISORDER

描述（改编自申请人的摘要）：本指导的目标 临床科学家发展奖（K 08）允许候选人 发展成为一个独立的临床研究者，通过追求一个程序， 脑解剖磁共振临床研究的培训和监督 核磁共振成像（MRI）的儿童双相情感障碍。 尽管井 有记录的儿童BPD的发病率和功能障碍，这种疾病仍然存在 儿童精神病理学中最有争议的话题之一， 结果，在研究最少的儿童精神疾病之一。 这 争议主要是疾病分类学上的。 毫无疑问，这些 有孩子。 然而，由于缺乏足够的科学数据， 童年的BPD产生了怀疑和缺席的恶性循环 的研究。 BPD诊断复杂化的主要因素是 儿童是ADHD的常见合并症。 关键的问题是 这些孩子是否患有多动症，BPD或两种疾病。 的分辨率 这个问题具有重要的临床意义。 为此，申请人提出了一项形态测量研究，旨在 解开儿童BPD与ADHD的共病。 四个样本， 由20名6-16岁的儿童组成，将研究：1）儿童 2）ADHD儿童，3）BPD儿童，以及4） 健康志愿者 该研究测试了四个相互竞争的假设，以确定 BPD+ADHD儿童是否有形态测量结果， 与ADHD儿童或儿童的临床相关性相似， 与BPD，或与ADHD和BPD的儿童，或者如果他们有独特的 调查结果。 如果得到资助，这项拟议中的工作将填补研究中的两个空白 文献：这将是1）最大的儿童BPD神经影像学研究 2）第一个MRI研究，测试有关关系的假设 ADHD和BPD的区别 通过揭示疾病分类学的争论，这项工作 将对这些儿童的诊断和治疗产生影响。 此外，候选人将接受儿童临床研究方法的培训 精神病学（20%的努力）的赞助下，约瑟夫比德曼， M.D.（共同导师），哈佛医学院精神病学教授， Verne Caviness，医学博士（共同导师），儿科神经病学教授， 哈佛医学院，让她掌握了方法， 儿童BPD的形态测量研究，强调评估 儿童的精神病理学及其MRI扫描评价。 博士 斯蒂芬Faraone，精神病学副教授，将担任 数据库管理和数据分析顾问， 生物统计学课程的正式教学培训（20%的努力）， 哈佛公共卫生学院。 通过让候选人集中时间 在获得必要的技能和精力，该奖项是一个重要的一步 在她的目标，追求独立的研究，在神经成像的儿童 狂躁症。

DESCRIPTION (Adapted from Applicant's Abstract): The goal of this Mentored Clinical Scientist Development Award (K08) is to permit the Candidate to develop into an independent clinical investigator by pursuing a program of training and supervised clinical research in brain anatomic magnetic resonance imaging (MRI) of childhood bipolar disorder. Despite the well documented morbidity and dysfunction of childhood BPD, the disorder remains one of the most controversial topics in child psychopathology and as a consequence, among the least researched child psychiatric disorders. This controversy is largely nosological. There is no disagreement that these children exist. Yet, it is the absence of adequate scientific data on childhood BPD that has generated a vicious cycle of skepticism and absence of research. A leading factor that complicates the diagnosis of BPD in children is the frequent comorbidity with ADHD. The critical question is whether these children have ADHD, BPD or both disorders. The resolution of this question has important clinical implications. To this end, the applicant proposes a morphometric study aimed at disentangling the comorbidity of childhood BPD with ADHD. Four samples, consisting of twenty 6-16 year old children, will be studied: 1) children with both ADHD and BPD 2) children with ADHD, 3) children with BPD, and 4) healthy volunteers. The study tests four competing hypotheses to determine whether children with BPD+ADHD have morphometric findings, in conjunction with clinical correlates that are similar to children with ADHD, or children with BPD, or with children with both ADHD and BPD, or if they have unique findings. If funded, the proposed work will fill two gaps in the research literature: it will be 1) the largest neuroimaging study of childhood BPD and 2) the first MRI study that tests hypotheses about the relationship between ADHD and BPD. By shedding light on the nosologic debate, this work will have implications for the diagnosis and treatment of these children. In addition, the Candidate will train in Clinical Research Methods in Child Psychiatry (20 percent effort) under the sponsorship of Joseph Biederman, M.D. (co-mentor), Professor of Psychiatry at Harvard Medical School and Verne Caviness, M.D. (co-mentor), Professor of Pediatric Neurology at Harvard Medical School, allowing her to master the methodology of morphometric studies in childhood BPD, emphasizing the assessment of psychopathology in the children and the evaluation of their MRI scans. Dr. Stephen Faraone, Associate Professor of Psychiatry, will serve as a consultant regarding data base management and data analysis and regarding Formal Didactic Training (20 percent effort) in biostatistics courses at the Harvard School of Public Health. By allowing the Candidate to focus time and energy on acquiring the necessary skills, the Award is an important step in her goal to pursue independent research in neuroimaging of childhood mania.