MR OF CEREBRAL OXYGENATION IN ISCHEMIA

候选人目标和职业发展计划：候选人是一名 介入神经放射学家，长期目标是成为 独立研究者，在学术领域承担临床责任 医学中心 候选人已掌握使用 正电子发射断层扫描（PET）用于脑血流动力学和 代谢测量。 该奖项将确保专门的时间和 发展知识和技能基础所需的指导 这是成功的长期调查所必需的。 该基金会将 在拟议的三年内，通过（1）获得 更深入地了解脑血管病理生理学和使用 PET通过参与NIH资助的项目进行研究 项目;（2）学习生理磁共振的高级技能 (MR)测量和（3）收集初步数据的发展 一个独立的项目 环境：环境是独特的，既有PET 以及MR专业知识和技术。 候选人的担保人 作为脑血管疾病的独立研究者 病理生理学。 同样，共同赞助人是一个 活跃的MR研究小组，在生理MR方面的工作得到认可 应用. 一个资助的计划项目，使用PET研究大脑 急性神经系统损伤患者血流动力学和代谢 将在本奖项的三年任期内进行。 研究建议：主要目的是研究MR用于 局部脑氧摄取分数（rOEF）测定 在人类身上。 初步数据显示，这些测量结果 重要的临床意义。 待检验的主要假设 脱氧血红蛋白敏感的MR图（称为血氧水平 依赖，BOLD或R2* 图），在校正血容量后，将 确定rOEF的区域增加。 一、MR的准确性 将评估脑血容量（rCBV）的测量。 这 将在30例患者中进行配对MR和PET研究， 颈动脉闭塞 接下来，通过直接测量法测量的rOEF与 颈静脉A-VDO 2采样和rCBV校正血氧水平依赖性 将在一系列猕猴中严格检查MR图 实验 最后，假设血氧水平 针对rCBV校正的相关图将准确识别区域 将在30例颈动脉稳定的患者中检测rOEF的变化 用PET和MR研究闭塞。

Candidate Goals and Career Development Plan: The candidate is an interventional neuroradiologist with a long term goal of becoming an independent investigator with clinical responsibilities in an academic medical center. The candidate has learned basic skills in the use of Positron Emission Tomography (PET) for cerebral hemodynamic and metabolic measurements. This award will secure the dedicated time and guidance needed to develop the foundation of knowledge and skills required for successful long term investigation. This foundation will be built over the proposed three years of the award by (1) gaining a deeper understanding of cerebrovascular pathophysiology and the use of PET for it's study through participation in a NIH funded Program Project; (2)learning advanced skills in physiologic magnetic resonance (MR) measurements and (3) gathering preliminary data for the development of an independent project Environment: The environment is unique in the availability of both PET and MR expertise and technology. The candidate's sponsor is well recognized as an independent investigator of cerebrovascular pathophysiology using PET. Similarly, the co-sponsor is director of an active MR research group, recognized for work in physiologic MR applications. A funded Program Project using PET to study cerebral hemodynamics and metabolism in patients with acute neurologic injury will be underway during the three year term of this award. Research Proposal: The primary aim is to investigate the use of MR for the measurement of regional cerebral oxygen extraction fraction (rOEF) in humans. Preliminary data indicate that these measurements have important clinical significance. The primary hypothesis to be tested is that deoxyhemoglobin sensitive MR maps (known as blood oxygen level dependent, BOLD or R2* maps), after correction for blood volume, will identify regional increases in rOEF. First, the accuracy of MR measurements of cerebral blood volume (rCBV) will be assessed. This will be accomplished with paired MR and PET studies in 30 patients with carotid occlusion. Next, the relationship of rOEF measured by direct jugular A-VDO2 sampling and rCBV corrected blood oxygen level dependent MR maps will be rigorously examined in a series of Macaque monkey experiments. Finally, the hypothesis that a blood oxygen level dependent map corrected for rCBV will accurately identify regional changes in rOEF will be tested in 30 patients with stable carotid occlusion studied with PET and MR.